about
FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac diseaseHax-1 identified as a two-pore channel (TPC)-binding proteinPhospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injectionPLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesisDysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case StudyDistinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic diseaseStructural insights into the human RyR2 N-terminal region involved in cardiac arrhythmiasMultiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells.Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.Recognition force microscopy/spectroscopy of ion channels: applications to the skeletal muscle Ca2+ release channel (RYR1).Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activationThe dynamics of MAPK inactivation at fertilization in mouse eggs.Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker regionRedistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytesDivergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggsIs PAWP the "real" sperm factor?The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCzeta.Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase CζToward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems.Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.Ca(2+) dynamics in oocytes from naturally-aged miceThe dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggsPresenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.N-terminus oligomerization is conserved in intracellular calcium release channels.Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.PLCζ and the initiation of Ca(2+) oscillations in fertilizing mammalian eggs.Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.Sperm-induced Ca2+ release during egg activation in mammals.Structural and functional interactions within ryanodine receptor.Egg Activation at Fertilization by a Soluble Sperm Protein.
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F A Lai
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0000-0003-2852-8547