Proteases display biased agonism at protease-activated receptors: location matters!
about
Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonistThrombin regulation of synaptic transmission and plasticity: implications for health and diseaseBiologic mechanisms of oral cancer pain and implications for clinical therapyNanotechnology-based drug delivery systems for treatment of oral cancer: a reviewProtein C anticoagulant and cytoprotective pathwaysCytoprotective-selective activated protein C therapy for ischaemic strokeEndometriosis, angiogenesis and tissue factorKallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cellsIn search of analgesia: emerging roles of GPCRs in pain.Parstatin, a novel protease-activated receptor 1-derived inhibitor of angiogenesis.Signal transduction by protease-activated receptorsLanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis.PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis.Allosteric modulation of protease-activated receptor signaling.Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection.The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivoProteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancersDefining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts.Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.Protease-activated receptors in hemostasis.Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cellsProteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impactProtease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1Biased signaling of protease-activated receptors.Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signalingModulation of PAR(1) signalling by benzimidazole compounds.Label-free optical biosensor with microfluidics for sensing ligand-directed functional selectivity on trafficking of thrombin receptor.Potent agonists of the protease activated receptor 2 (PAR2).Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.Biased agonism.Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdalaChanges in Neuronal Signaling and Cell Stress Response Pathways are Associated with a Multigenic Response of Drosophila melanogaster to DDT Selection.Cell painting with an engineered EPCR to augment the protein C system.The intracellular carboxyl tail of the PAR-2 receptor controls intracellular signaling and cell death.
P2860
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P2860
Proteases display biased agonism at protease-activated receptors: location matters!
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Proteases display biased agonism at protease-activated receptors: location matters!
@ast
Proteases display biased agonism at protease-activated receptors: location matters!
@en
type
label
Proteases display biased agonism at protease-activated receptors: location matters!
@ast
Proteases display biased agonism at protease-activated receptors: location matters!
@en
prefLabel
Proteases display biased agonism at protease-activated receptors: location matters!
@ast
Proteases display biased agonism at protease-activated receptors: location matters!
@en
P2093
P2860
P356
P1476
Proteases display biased agonism at protease-activated receptors: location matters!
@en
P2093
Angela Russo
JoAnn Trejo
Unice J K Soh
P2860
P356
10.1124/MI.9.2.8
P577
2009-04-01T00:00:00Z