Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.
about
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domainsMechanisms of granulin deficiency: lessons from cellular and animal modelsInactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>AWhite matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort.Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions.Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance.Progranulin mutations as risk factors for Alzheimer diseaseFrontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management.Progress in frontotemporal dementia research.The behavioral variant of frontotemporal dementia: linking neuropathology to social cognition.PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway.Prosaposin is a regulator of progranulin levels and oligomerization.Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells.Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Serum C-Peptide, Visfatin, Resistin, and Ghrelin are Altered in Sporadic and GRN-Associated Frontotemporal Lobar Degeneration.Modulation of Regulatory T Cell Activity by TNF Receptor Type II-Targeting Pharmacological Agents.Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupBiomarkers in frontotemporal dementiaAtrophy and microglial distribution in primary progressive aphasia with transactive response DNA-binding protein-43 kDaProteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases
P2860
Q24337327-E02275B2-F444-4D0A-87F1-212217C4C72BQ26824221-51848552-08F1-41DA-9D34-04DD9F8958ECQ28483833-23AA3771-E0AB-4321-AB90-9A8A5766A8BDQ33676267-62165399-0AB6-49C7-AE4D-8D9784800FB2Q35541825-30416817-C6EE-4B58-B203-D2025F32C54FQ35859333-54047D05-C3BF-4A40-8563-53897B8EEBFBQ36189372-EFF67B83-6619-4B75-9FD0-754D17B679F1Q36242938-5666EF97-1B58-4771-A695-8C7C50C8A41EQ36294670-EC6F0546-A602-4141-B91F-4426C1F5B85BQ36603819-9DA620A6-58F9-4F26-A02B-422EE35B432EQ36656492-0C51AFCA-CB76-4548-8FEF-428906E5899CQ37095837-ECE22261-FA3A-451A-9EEE-3AFD15A28300Q38040822-87936B34-7A78-4DA4-B8BB-E261ECA50791Q38065721-6E3D3CCE-2783-4235-9BCF-A0E03A1147FEQ38078773-D3B5977A-D8CE-446E-B46B-E451D4AADA90Q38767538-67643964-61DF-491A-AF62-9FC001705D1DQ38847140-9EE6EFF5-486C-44CE-A802-FC012F9E7E32Q38942093-F751BF0A-70FD-4C45-ADB5-CD565A75054AQ43856158-C75149F0-3D16-49E5-8A78-F87F8E832C40Q45417639-1E0ECEEE-61AD-4CE2-98EA-AC9E590CACB7Q47623958-CA674C2B-A67F-4D00-993F-6C9502E7A6B2Q47922942-CC671D57-4AF8-4E76-9353-89ECF93942B2Q55007606-D69F4592-5178-4967-B40E-93B12370F6E8Q57168893-4D5DDF19-A5BA-4355-8762-51E865221D5EQ57911950-4D53F2B3-E7B8-4E79-9DA8-FA7337CB13F7Q58493793-7E5F2AD6-A35B-444B-A437-44E931ABB10DQ58711278-EF9E0218-B8A0-49FB-958C-EBF31BBE71C4
P2860
Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Loss of function mutations in ...... l lobar degeneration patients.
@ast
Loss of function mutations in ...... l lobar degeneration patients.
@en
type
label
Loss of function mutations in ...... l lobar degeneration patients.
@ast
Loss of function mutations in ...... l lobar degeneration patients.
@en
prefLabel
Loss of function mutations in ...... l lobar degeneration patients.
@ast
Loss of function mutations in ...... l lobar degeneration patients.
@en
P2093
P2860
P50
P356
P1476
Loss of function mutations in ...... l lobar degeneration patients.
@en
P2093
Alessandro Padovani
Antonella Alberici
Gianfranco Spalletta
Paola Bossù
Silvana Archetti
P2860
P2888
P356
10.1186/1742-2094-8-65
P577
2011-06-06T00:00:00Z
P5875
P6179
1048911243