In situ kinase profiling reveals functionally relevant properties of native kinases. - Wikidata - awgldk - TriplyDB

In situ kinase profiling reveals functionally relevant properties of native kinases.

In situ kinase profiling reveals functionally relevant properties of native kinases.

http://www.wikidata.org/entity/Q35125012

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Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach Ten things you should know about protein kinases: IUPHAR Review 14 The dynamic nature of the kinome Developing irreversible inhibitors of the protein kinase cysteinome Affinity-Based Probes Based on Type II Kinase Inhibitors Active site profiling reveals coupling between domains in SRC-family kinases An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy Mediator kinase inhibition further activates super-enhancer-associated genes in AML Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics Chemical Proteomic Profiling of Human Methyltransferases Synergistic interactions with PI3K inhibition that induce apoptosis.StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.How chemoproteomics can enable drug discovery and development Target validation using chemical probes.Pharmacological targeting of the pseudokinase Her3 A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.Computational methods and opportunities for phosphorylation network medicine Profiling native kinases by immuno-assisted activity-based profiling.A targeted quantitative proteomics strategy for global kinome profiling of cancer cells and tissues.Rapid profiling of protein kinase inhibitors by quantitative proteomics.A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.Development of small molecules targeting the pseudokinase Her3.Cell permeable affinity- and activity-based probes.Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis New approaches for dissecting protease functions to improve probe development and drug discovery Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death.A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions.Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.

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In situ kinase profiling reveals functionally relevant properties of native kinases.

http://www.wikidata.org/entity/Q35125012

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

In situ kinase profiling reveals functionally relevant properties of native kinases.

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In situ kinase profiling reveals functionally relevant properties of native kinases.

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type

label

In situ kinase profiling reveals functionally relevant properties of native kinases.

@ast

In situ kinase profiling reveals functionally relevant properties of native kinases.

@en

prefLabel

In situ kinase profiling reveals functionally relevant properties of native kinases.

@ast

In situ kinase profiling reveals functionally relevant properties of native kinases.

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J.CHEMBIOL.2011.04.011

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Chemistry and Biology

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In situ kinase profiling reveals functionally relevant properties of native kinases.

@en

P2093

Arwin Aban

http://www.w3.org/2001/XMLSchema#string

Brian Nordin

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Chris Herring

http://www.w3.org/2001/XMLSchema#string

David Zhou

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Eric Okerberg

http://www.w3.org/2001/XMLSchema#string

Heidi Brown

http://www.w3.org/2001/XMLSchema#string

Helge Weissig

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Jiangyue Wu

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Jianming Zhang

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Jiing-Dwan Lee

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P2860

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

The protein kinase complement of the human genome

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Active Ras induces heterodimerization of cRaf and BRaf

A quantitative analysis of kinase inhibitor selectivity

The discovery of potent cRaf1 kinase inhibitors

Protein kinases--the major drug targets of the twenty-first century?

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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699-710

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10.1016/J.CHEMBIOL.2011.04.011

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6

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18

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21700206

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3142620

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