about
Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signalingDiscovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activityKappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytesNovel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICSSmall molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathwaysHigh-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cellsInhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretchRegulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2.Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity.Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatasesCigarette smoke upregulates rat coronary artery endothelin receptors in vivoApplication of a homogenous membrane potential assay to assess mitochondrial function.Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases.Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptorsInhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Chemical interrogation of the malaria kinome.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.In situ kinase profiling reveals functionally relevant properties of native kinases.Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals.Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptorsCellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention.Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.Raf kinases: oncogenesis and drug discovery.Insulin stimulates primary beta-cell proliferation via Raf-1 kinase.High throughput screening reveals several new classes of glutamate dehydrogenase inhibitorsGain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3REnhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity.IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathwayThe RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics.Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans.Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity.C-Raf is associated with disease progression and cell proliferation in a subset of melanomas.Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The discovery of potent cRaf1 kinase inhibitors
@ast
The discovery of potent cRaf1 kinase inhibitors
@en
The discovery of potent cRaf1 kinase inhibitors
@nl
type
label
The discovery of potent cRaf1 kinase inhibitors
@ast
The discovery of potent cRaf1 kinase inhibitors
@en
The discovery of potent cRaf1 kinase inhibitors
@nl
prefLabel
The discovery of potent cRaf1 kinase inhibitors
@ast
The discovery of potent cRaf1 kinase inhibitors
@en
The discovery of potent cRaf1 kinase inhibitors
@nl
P2093
P1476
The discovery of potent cRaf1 kinase inhibitors
@en
P2093
O B McDonald
R D Rutkowske
R N Hunter
P304
P356
10.1016/S0960-894X(99)00668-X
P407
P577
2000-02-01T00:00:00Z