Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.
about
CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNPRibavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?A review of the association between osteosarcoma metastasis and protein translationOncolytic virotherapy using herpes simplex virus: how far have we come?Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4EImproved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective EffectseIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognitionDesign of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisationAntitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrolTargeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotideThe crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferationRibavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA capProtein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expressionSubcellular proteomics revealed the epithelial-mesenchymal transition phenotype in lung cancer.Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles.Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic salineThe role of c-Src in integrin (α6β4) dependent translational controlRoles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Targeting the eIF4F translation initiation complex: a critical nexus for cancer developmentCap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons.Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartmentEIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteinsTargets and mechanisms for the regulation of translation in malignant transformation.The role of translation in neoplastic transformation from a pathologist's point of view.Postgenomic global analysis of translational control induced by oncogenic signaling.The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.The ezrin metastatic phenotype is associated with the initiation of protein translation.The eIF4E RNA regulon promotes the Akt signaling pathway.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Targeting prostate cancer based on signal transduction and cell cycle pathways.Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen.
P2860
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P2860
Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Translational control and meta ...... n of metastasis-related mRNAs.
@ast
Translational control and meta ...... n of metastasis-related mRNAs.
@en
type
label
Translational control and meta ...... n of metastasis-related mRNAs.
@ast
Translational control and meta ...... n of metastasis-related mRNAs.
@en
prefLabel
Translational control and meta ...... n of metastasis-related mRNAs.
@ast
Translational control and meta ...... n of metastasis-related mRNAs.
@en
P356
P1476
Translational control and meta ...... n of metastasis-related mRNAs.
@en
P2093
Jeremy R Graff
Stephen G Zimmer
P2888
P304
P356
10.1023/A:1022943419011
P577
2003-01-01T00:00:00Z
P6179
1013004629