Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.
about
Vitamin C: update on physiology and pharmacologyThe LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesisDisulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallinComprehensive analysis of maillard protein modifications in human lenses: effect of age and cataractMaillard degradation pathways of vitamin C.Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model.Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin CGenistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat.Ascorbic acid and the brain: rationale for the use against cognitive decline.UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.Nutritional modulation of cataractAre ancient proteins responsible for the age-related decline in health and fitness?Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysisApplied Healthspan engineering.Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung.Activation of unfolded protein response in transgenic mouse lenses.Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.Vitamin C degradation products and pathways in the human lensAntioxidant capacity of lenses with age-related cataractGlycation of bovine serum albumin by ascorbate in vitro: Possible contribution of the ascorbyl radical?A Class I UV-blocking (senofilcon A) soft contact lens prevents UVA-induced yellow fluorescence and NADH loss in the rabbit lens nucleus in vivo.Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse LensInhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging.Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic diseaseLens aging: effects of crystallins.Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.The effects of L-arginine, alone and combined with vitamin C, on mineral status in relation to its antidiabetic, anti-inflammatory, and antioxidant properties in male rats on a high-fat diet.The pathogenic role of Maillard reaction in the aging eye.The challenge of increasing vitamin C content in plant foods.Pharmacological therapies for cataract and refractive errors: landscaping niches of ocular drug patenting.Oxidation as an important factor of protein damage: Implications for Maillard reaction.Small molecules, both dietary and endogenous, influence the onset of lens cataracts.Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches.Antioxidant delivery pathways in the anterior eye.The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteinsRole of zinc along with ascorbic acid and folic acid during long-term in vitro albumin glycation.Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.Probing Protein Glycation by Chromatography and Mass Spectrometry: Analysis of Glycation Adducts.
P2860
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P2860
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@ast
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@en
type
label
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@ast
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@en
prefLabel
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@ast
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@en
P2093
P2860
P356
P1476
Vitamin C mediates chemical ag ...... on in a humanized mouse model.
@en
P2093
Beryl J Ortwerth
Christopher Strauch
Lixing W Reneker
Mark E Obrenovich
Rongzhu Cheng
Simon M Jarvis
Vincent M Monnier
Xingjun Fan
P2860
P304
16912-16917
P356
10.1073/PNAS.0605101103
P407
P577
2006-10-30T00:00:00Z