A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation
about
Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neuronsOncogenic RIT1 mutations in lung adenocarcinoma.Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiationRap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationSrc-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiationThe cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.Activation of MEK/ERK Signaling by PACAP in Guinea Pig Cardiac Neurons.Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotectionProstanoid receptor EP2 as a therapeutic targetRit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.Regulation of PC12 cell differentiation by cAMP signaling to ERK independent of PKA: do all the connections add up?Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.Epac and PKA: a tale of two intracellular cAMP receptors.PKA and Epac synergistically inhibit smooth muscle cell proliferation.Claulansine F promotes neuritogenesis in PC12 cells via the ERK signaling pathwayA rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress.An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance.Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways.Putative role of prostaglandin receptor in intracerebral hemorrhage.Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.Ras family small GTPase-mediated neuroprotective signaling in stroke.Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade.Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity.Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress.cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis.Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2Rit subfamily small GTPases: regulators in neuronal differentiation and survival.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.EPAC proteins transduce diverse cellular actions of cAMP.Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.Role of Epac in brain and heart.Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis.Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP-mediated activation of ERK and p38 MAP kinases.
P2860
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P2860
A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@ast
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@en
type
label
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@ast
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@en
prefLabel
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@ast
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@en
P2093
P2860
P356
P1476
A novel cyclic AMP-dependent E ...... iated neuronal differentiation
@en
P2093
Douglas A Andres
Geng-Xian Shi
Holger Rehmann
P2860
P304
P356
10.1128/MCB.00332-06
P407
P577
2006-09-25T00:00:00Z