Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. - Wikidata - awgldk - TriplyDB

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

http://www.wikidata.org/entity/Q35134003

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Identification of druggable cancer driver genes amplified across TCGA datasets Cancer vulnerabilities unveiled by genomic loss β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3 Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer Genome-wide analysis of microRNA and mRNA expression signatures in cancer Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes Genetic screens and functional genomics using CRISPR/Cas9 technology Oncogenic Signaling Adaptor Proteins A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation Proteogenomic characterization of human colon and rectal cancer SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 Pulmonary adenocarcinoma: a renewed entity in 2011 The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection Assessment of FBA Based Gene Essentiality Analysis in Cancer with a Fast Context-Specific Network Reconstruction Method ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state Public data and open source tools for multi-assay genomic investigation of disease ScreenBEAM: a novel meta-analysis algorithm for functional genomics screens via Bayesian hierarchical modeling RNAi screening comes of age: improved techniques and complementary approaches OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines Systematic Quality Control Analysis of LINCS Data Integrated genetic and pharmacologic interrogation of rare cancers Selective inhibition of tumor oncogenes by disruption of super-enhancers Genetic screens in human cells using the CRISPR-Cas9 system Empowering biologists with multi-omics data: colorectal cancer as a paradigm.Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis.High-throughput in situ cell electroporation microsystem for parallel delivery of single guide RNAs into mammalian cells Lean Big Data integration in systems biology and systems pharmacology.Integration of genomic data enables selective discovery of breast cancer drivers.In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAFV600E in melanoma.Publisher’s Note:Abstraction for data integration:Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction.Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.Gene regulatory pattern analysis reveals essential role of core transcriptional factors' activation in triple-negative breast cancer.High-resolution network biology: connecting sequence with function.Use of RNAi screens to uncover resistance mechanisms in cancer cells and identify synthetic lethal interactions.

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

http://www.wikidata.org/entity/Q35134003

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Proceedings of the National Academy of Sciences of the United States of America

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Systematic investigation of ge ...... ependencies in ovarian cancer.

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Barbara A Weir

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Biao Luo

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David E Root

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Glenn S Cowley

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Guozhi Jiang

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Hiu Wing Cheung

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Jessica Hsiao

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Joshua Gould

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Justine A Scott

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Levi D Ali

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P2860

Ovarian carcinoma subtypes are different diseases: implications for biomarker studies

Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

Characterizing the cancer genome in lung adenocarcinoma.

The Catalogue of Somatic Mutations in Cancer (COSMIC)

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Integrated genomic analyses of ovarian carcinoma

Follicular cells of the thyroid gland require Pax8 gene function

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

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12372-12377

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10.1073/PNAS.1109363108

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30

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108

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Jill P. Mesirov

Alexandra East-Seletsky

Aviad Tsherniak

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Patrick H Lizotte

Jordi Barretina

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2011-07-11T00:00:00Z

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51483521

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