The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery.
about
Artificial neural network models for prediction of intestinal permeability of oligopeptides.Assessment of in silico models for fraction of unbound drug in human liver microsomes.Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery.Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discoverypkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.Drug discovery in academia.BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.Trials, tribulations, and trends in tumor modeling in mice.Three-dimensional cellular microarray for high-throughput toxicology assaysThe road map to oral bioavailability: an industrial perspective.Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection.Novel MS solutions inspired by MIST.N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.Current drug targets for helminthic diseases.Pros and cons of methods used for the prediction of oral drug absorption.Excretion and toxicity evaluation of 131I-Sennoside A as a necrosis-avid agent.QSAR Prediction of Passive Permeability in the LLC-PK1 Cell Line: Trends in Molecular Properties and Cross-Prediction of Caco-2 Permeabilities.Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41.Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.The Development of Models Based on Linear and Nonlinear Multivariate Methods to Predict ADME/PK Properties Using Physicochemical Properties of Kinase, Protease Inhibitors, and GPCR Antagonists.Indirect readout in drug-DNA recognition: role of sequence-dependent DNA conformation.Prediction of Effective Drug Combinations by an Improved Naïve Bayesian Algorithm.Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS.Synthesis, characterization, in silico ADMET prediction, and protein binding analysis of a novel zinc(II) Schiff-base complex: Application of multi-spectroscopic and computational techniques.Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes.Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.Meranzin Hydrate Induces Similar Effect to Fructus Aurantii on Intestinal Motility through Activation of H1 Histamine Receptors
P2860
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P2860
The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The role of absorption, distri ...... nd toxicity in drug discovery.
@ast
The role of absorption, distri ...... nd toxicity in drug discovery.
@en
type
label
The role of absorption, distri ...... nd toxicity in drug discovery.
@ast
The role of absorption, distri ...... nd toxicity in drug discovery.
@en
prefLabel
The role of absorption, distri ...... nd toxicity in drug discovery.
@ast
The role of absorption, distri ...... nd toxicity in drug discovery.
@en
P2093
P356
P1476
The role of absorption, distri ...... nd toxicity in drug discovery.
@en
P2093
Diana C Sahakian
Jinghai J Xu
Robert J Polzer
Sonia M F de Morais
Steven M Winter
P304
P356
10.2174/1568026033452096
P577
2003-01-01T00:00:00Z