Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

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Q35145016

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Leishmania carbon metabolism in the macrophage phagolysosome- feast or famine?Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity LC-MS metabolomics from study design to data-analysis - using a versatile pathogen as a test case.The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans.Metabolic variation during development in culture of Leishmania donovani promastigotes.Mass spectrometric analysis of L-cysteine metabolism: physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica.Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses Characterization of metabolically quiescent Leishmania parasites in murine lesions using heavy water labeling.Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.Dissecting Leishmania infantum Energy Metabolism - A Systems Perspective.Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell Role of cytosolic glyceraldehyde-3-phosphate dehydrogenase in visceral organ infection by Leishmania donovani Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector Determination of antiprotozoal drug mechanisms by metabolomics approaches.Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review.Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei.Capillary electrophoresis reveals polyamine metabolism modulation in Leishmania (Leishmania) amazonensis wild type and arginase knockout mutants under arginine starvation.Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.Analysis of ethyl glucuronide and ethyl sulfate using aqueous normal-phase chromatography with mass spectrometry.Revealing the mystery of metabolic adaptations using a genome scale model of Leishmania infantum Gluconeogenesis in Leishmania mexicana: contribution of glycerol kinase, phosphoenolpyruvate carboxykinase, and pyruvate phosphate dikinase L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance.Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation.Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania.A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine.Characterisation of a Putative Glutamate 5- Kinase from Leishmania donovani.The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.

P2860

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P2860

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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