Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
about
The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum.Targeting pathogen metabolism without collateral damage to the hostIdentification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial CompoundsStudies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysisIdentity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transportersThe Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic ScreensSubstrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scaleAquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium bergheiMolecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug targetLife cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentialityProteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.Protease-associated cellular networks in malaria parasite Plasmodium falciparum.1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents.Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress.A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogsUse of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycleNutrient transport and pathogenesis in selected parasitic protozoa.Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa.Proteases in malaria parasites - a phylogenomic perspective.Why is the Plasmodium falciparum hexose transporter a promising new drug target?Antimalarial drug discovery: efficacy models for compound screening.Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum.Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose TransportersMolecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption.Identification, expression and characterisation of a Babesia bovis hexose transporter.Recent highlights in antimalarial drug resistance and chemotherapy research.Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis.Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium.An expression system to screen for inhibitors of parasite glucose transportersTransporters for drug delivery and as drug targets in parasitic protozoa.GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection.Versatility in the acquisition of energy and carbon sources by the Apicomplexa.Novel antimalarial drug targets: hope for new antimalarial drugs.Glucose-6-phosphate metabolism in Plasmodium falciparum.Membrane transport in the malaria parasite and its host erythrocyte.Transport proteins of parasitic protists and their role in nutrient salvage.Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Drug target identification in protozoan parasites.
P2860
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P2860
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@ast
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@en
type
label
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@ast
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@en
prefLabel
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@ast
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.
@en
P2860
P921
P356
P1476
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
@en
P2093
Christophe Morin
Ursula Eckstein-Ludwig
P2860
P304
P356
10.1073/PNAS.1330865100
P407
P577
2003-06-05T00:00:00Z