Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
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Mitochondrial targeting of electron scavenging antioxidants: regulation of selective oxidation vs random chain reactionsCytochrome c/cardiolipin relations in mitochondria: a kiss of deathEnzymes of the cyclooxygenase pathways of prostanoid biosynthesisThe cyclooxygenasesEndocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathwaysNitro-fatty acids: novel anti-inflammatory lipid mediatorsA Covalent Linker Allows for Membrane Targeting of an Oxylipin Biosynthetic Complex † ‡Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2Lipid peroxidation and its toxicological implicationsMolecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behaviorMolecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivityHuman CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoidsThe self-organizing fractal theory as a universal discovery method: the phenomenon of lifeSynthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabelSubstrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentationAsymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.Cyclooxygenases: structural and functional insights.ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations.Heme enzyme structure and function.A Revised Mechanism for Human Cyclooxygenase-2.Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents.Partnering between monomers of cyclooxygenase-2 homodimersA critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoidsNitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2.Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione.Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradationApplications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistryInflammation and cancer: chemical approaches to mechanisms, imaging, and treatment.Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2.Competition and allostery govern substrate selectivity of cyclooxygenase-2.Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid.Nitroarachidonic acid prevents NADPH oxidase assembly and superoxide radical production in activated macrophagesObservation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2.Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation.Control of oxygenation in lipoxygenase and cyclooxygenase catalysisA perspective on free radical autoxidation: the physical organic chemistry of polyunsaturated fatty acid and sterol peroxidation.
P2860
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P2860
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@ast
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@en
type
label
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@ast
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@en
prefLabel
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@ast
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@en
P356
P1433
P1476
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
@en
P2093
Carol A Rouzer
Lawrence J Marnett
P304
P356
10.1021/CR000068X
P577
2003-06-01T00:00:00Z