G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription.
about
Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivityUse of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomyThe cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNAThe A-nucleotide preference of HIV-1 in the context of its structured RNA genomeThe biased nucleotide composition of HIV-1 triggers type I interferon response and correlates with subtype D increased pathogenicityAPOBEC3G contributes to HIV-1 variation through sublethal mutagenesisRestriction of retroviral replication by APOBEC3G/F and TRIM5alphaIntracellular immunity to HIV-1: newly defined retroviral battles inside infected cells.The APOBEC3 family of retroelement restriction factorsUnusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1Accurate reconstruction of a known HIV-1 transmission history by phylogenetic tree analysis3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.In silico segmentations of lentivirus envelope sequences.APOBEC3G inhibits elongation of HIV-1 reverse transcripts.Quasispecies theory and the behavior of RNA viruses.Molecular evidence for nosocomial transmission of human immunodeficiency virus from a surgeon to one of his patientsDeoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rateInteractions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells.Modeling and optimization of populations subject to time-dependent mutation.Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoformsIn vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients.APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon.Population dynamics of HIV-1 inferred from gene sequences.Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granulesMechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionInhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection.Long-Range HIV Genotyping Using Viral RNA and Proviral DNA for Analysis of HIV Drug Resistance and HIV Clustering.Tempo and mode of nucleotide substitutions in gag and env gene fragments in human immunodeficiency virus type 1 populations with a known transmission historyHypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations.Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.Comparison of G-to-A mutation frequencies induced by APOBEC3 proteins in H9 cells and peripheral blood mononuclear cells in the context of impaired processivities of drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants.Hypermutagenic PCR involving all four transitions and a sizeable proportion of transversions.In search of a function for the most frequent naturally-occurring length polymorphism (MFNLP) of the HIV-1 LTR: retaining functional coupling, of Nef and RBF-2, at RBEIII?Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine.APOBEC proteins and intrinsic resistance to HIV-1 infectionDefining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates.
P2860
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P2860
G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription.
description
1994 nî lūn-bûn
@nan
1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
G-->A hypermutation of the hum ...... during reverse transcription.
@ast
G-->A hypermutation of the hum ...... during reverse transcription.
@en
type
label
G-->A hypermutation of the hum ...... during reverse transcription.
@ast
G-->A hypermutation of the hum ...... during reverse transcription.
@en
prefLabel
G-->A hypermutation of the hum ...... during reverse transcription.
@ast
G-->A hypermutation of the hum ...... during reverse transcription.
@en
P2093
P2860
P356
P1476
G-->A hypermutation of the hum ...... during reverse transcription.
@en
P2093
Vartanian JP
Wain-Hobson S
P2860
P304
P356
10.1073/PNAS.91.8.3092
P407
P577
1994-04-01T00:00:00Z