Mutant IDH is sufficient to initiate enchondromatosis in mice.
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FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling.The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.The Emerging Hallmarks of Cancer MetabolismIdh1 mutations contribute to the development of T-cell malignancies in genetically engineered miceCharacteristics of gliomas in patients with somatic IDH mosaicism.Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.IDH mutations in cancer and progress toward development of targeted therapeutics.Glutamate and α-ketoglutarate: key players in glioma metabolism.Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit.Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference.Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond.Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance.IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma.IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.
P2860
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P2860
Mutant IDH is sufficient to initiate enchondromatosis in mice.
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@ast
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@en
type
label
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@ast
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@en
prefLabel
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@ast
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@en
P2093
P2860
P356
P1476
Mutant IDH is sufficient to initiate enchondromatosis in mice.
@en
P2093
Angela Weng
Benjamin A Alman
Bryan E Snow
Camelia Gliser
Heather Whetstone
Jason Rockel
Jay Wunder
Kimberly Straley
Lisa D Jones
Makoto Hirata
P2860
P304
P356
10.1073/PNAS.1424400112
P407
P577
2015-02-17T00:00:00Z