Mutant IDH is sufficient to initiate enchondromatosis in mice. - Wikidata - awgldk - TriplyDB

Mutant IDH is sufficient to initiate enchondromatosis in mice.

Mutant IDH is sufficient to initiate enchondromatosis in mice.

http://www.wikidata.org/entity/Q35156925

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FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling.The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.The Emerging Hallmarks of Cancer Metabolism Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice Characteristics of gliomas in patients with somatic IDH mosaicism.Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.IDH mutations in cancer and progress toward development of targeted therapeutics.Glutamate and α-ketoglutarate: key players in glioma metabolism.Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit.Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference.Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond.Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance.IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma.IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

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P2860

Mutant IDH is sufficient to initiate enchondromatosis in mice.

http://www.wikidata.org/entity/Q35156925

description

2015 nî lūn-bûn

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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

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2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Mutant IDH is sufficient to initiate enchondromatosis in mice.

@ast

Mutant IDH is sufficient to initiate enchondromatosis in mice.

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type

label

Mutant IDH is sufficient to initiate enchondromatosis in mice.

@ast

Mutant IDH is sufficient to initiate enchondromatosis in mice.

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prefLabel

Mutant IDH is sufficient to initiate enchondromatosis in mice.

@ast

Mutant IDH is sufficient to initiate enchondromatosis in mice.

@en

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PNAS.1424400112

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Mutant IDH is sufficient to initiate enchondromatosis in mice.

@en

P2093

Angela Weng

http://www.w3.org/2001/XMLSchema#string

Benjamin A Alman

http://www.w3.org/2001/XMLSchema#string

Bryan E Snow

http://www.w3.org/2001/XMLSchema#string

Camelia Gliser

http://www.w3.org/2001/XMLSchema#string

Heather Whetstone

http://www.w3.org/2001/XMLSchema#string

Jason Rockel

http://www.w3.org/2001/XMLSchema#string

Jay Wunder

http://www.w3.org/2001/XMLSchema#string

Kimberly Straley

http://www.w3.org/2001/XMLSchema#string

Lisa D Jones

http://www.w3.org/2001/XMLSchema#string

Makoto Hirata

http://www.w3.org/2001/XMLSchema#string

P2860

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

IDH1 and IDH2 mutations in gliomas

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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2829-2834

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scholarly article

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10.1073/PNAS.1424400112

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2015-02-17T00:00:00Z

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25730874

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