Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
about
Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cellsBGLAP is expressed in pancreatic cancer cells and increases their growth and invasionStructural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaSmad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cellsIsolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiationMenin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradationSrc kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasmHistone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent mannerRegulation of osteocalcin gene expression by a novel Ku antigen transcription factor complexFIAT represses ATF4-mediated transcription to regulate bone mass in transgenic miceRunt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivityEndogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cellsThe zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathwaysAsporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralizationTranscriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressorsTranscriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activationA WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determinationRunx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoterLoss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinasesTIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitroDownregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesisIndian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationTranscriptional regulation of osteoblastsBMP type I receptor inhibition reduces heterotopic [corrected] ossificationControl of RANKL gene expressionMMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesEndogenous Msx1 antisense transcript: in vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammalsRepression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNAGeneral transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesA RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasiaDoubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activityModulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancerHey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cellsCHIP promotes Runx2 degradation and negatively regulates osteoblast differentiationRunx3 negatively regulates Osterix expression in dental pulp cellsTranscriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZThe Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
P2860
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P2860
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@ast
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@en
type
label
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@ast
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@en
prefLabel
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@ast
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@en
P2093
P3181
P1433
P1476
Targeted disruption of Cbfa1 r ...... rational arrest of osteoblasts
@en
P2093
Bronson RT
Kishimoto T
Kitamura Y
P304
P3181
P356
10.1016/S0092-8674(00)80258-5
P407
P577
1997-05-30T00:00:00Z