B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.
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Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.B cell receptor editing in tolerance and autoimmunityAutoreactivity by design: innate B and T lymphocytesReceptor editing is the main mechanism of B cell tolerance toward membrane antigensRas activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation.Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodiesB-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signalingReceptor editing in lymphocyte development and central tolerance.Receptor revision and systemic lupus.Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escapeTolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.Visualization of the genesis and fate of isotype-switched B cells during a primary immune responseAn immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune systemBruton's tyrosine kinase is essential for human B cell toleranceReceptor editing and genetic variability in human autoreactive B cells.A role for interferon regulatory factor 4 in receptor editing.A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.Tolerance checkpoints in B-cell development: Johnny B good.Regulatory B cells mediate tolerance to apoptotic self in health: implications for disease.Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.Positive selection of B cells expressing low densities of self-reactive BCRsB-cell tolerance in transplantation: is repertoire remodeling the answer?The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2.Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes.BAFF-R expression correlates with positive selection of immature B cells.IgH isotype-specific B cell receptor expression influences B cell fate.Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance.
P2860
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P2860
B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
B cell receptor expression lev ...... ptor editing versus selection.
@ast
B cell receptor expression lev ...... ptor editing versus selection.
@en
type
label
B cell receptor expression lev ...... ptor editing versus selection.
@ast
B cell receptor expression lev ...... ptor editing versus selection.
@en
prefLabel
B cell receptor expression lev ...... ptor editing versus selection.
@ast
B cell receptor expression lev ...... ptor editing versus selection.
@en
P2093
P2860
P356
P1476
B cell receptor expression lev ...... eptor editing versus selection
@en
P2093
P2860
P304
P356
10.1073/PNAS.130182597
P407
P577
2000-06-01T00:00:00Z