B lymphocytes may escape tolerance by revising their antigen receptors - Wikidata - awgldk - TriplyDB

B lymphocytes may escape tolerance by revising their antigen receptors

B lymphocytes may escape tolerance by revising their antigen receptors

http://www.wikidata.org/entity/Q36361618

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A role for MHC class II antigen processing in B cell development.Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching Lack of allelic exclusion in B cell chronic lymphocytic leukemia The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation Defects in Germinal Center Selection in SLE Immunological aspects in chronic lymphocytic leukemia (CLL) development Primary immunoglobulin repertoire development: time and space matter B cell receptor editing in tolerance and autoimmunity Receptor editing is the main mechanism of B cell tolerance toward membrane antigens Light chain editors of anti-DNA receptors in human B cells Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosus Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.Receptor selection in B and T lymphocytes.Revising B cell receptors An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.Deletion of immunoglobulin beta in developing B cells leads to cell death.Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production Central B-cell tolerance: where selection begins.B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study A stepwise epigenetic process controls immunoglobulin allelic exclusion.Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation.Receptor editing in lymphocyte development and central tolerance.Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia.Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.Receptor revision and systemic lupus.Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.Alternative mechanisms of receptor editing in autoreactive B cells.Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificities Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodies.B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.TLR7 influences germinal center selection in murine SLE.

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B lymphocytes may escape tolerance by revising their antigen receptors

http://www.wikidata.org/entity/Q36361618

description

1993 nî lūn-bûn

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1993年の論文

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1993年学术文章

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1993年学术文章

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1993年学术文章

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1993年学术文章

@zh-my

1993年学术文章

@zh-sg

1993年學術文章

@yue

1993年學術文章

@zh

1993年學術文章

@zh-hant

name

B lymphocytes may escape tolerance by revising their antigen receptors

@ast

B lymphocytes may escape tolerance by revising their antigen receptors

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type

label

B lymphocytes may escape tolerance by revising their antigen receptors

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B lymphocytes may escape tolerance by revising their antigen receptors

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prefLabel

B lymphocytes may escape tolerance by revising their antigen receptors

@ast

B lymphocytes may escape tolerance by revising their antigen receptors

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Journal of Experimental Medicine

P1476

B lymphocytes may escape tolerance by revising their antigen receptors

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P2093

J Erikson

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M Weigert

http://www.w3.org/2001/XMLSchema#string

S Litwin

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P2860

Most peripheral B cells in mice are ligand selected.

Utilization of V kappa families and V kappa exons. Implications for the available B cell repertoire.

Rapid transfer of DNA from agarose gels to nylon membranes

Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6.

Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segment in a murine B cell line.

Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells.

Clonal deletion of autospecific B lymphocytes.

Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA.

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1165-1173

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4

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2190988

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