Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres
about
DNA end resection: many nucleases make light workRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairEnd-resection at DNA double-strand breaks in the three domains of lifeHuman Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeresRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesSite-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleasesA novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere lossProtection of telomeres by a conserved Stn1-Ten1 complex.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationGenetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeastPot1 inactivation leads to rampant telomere resection and loss in one cell cycle.Timing is everything: cell cycle control of Rad52Protection and replication of telomeres in fission yeast.To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?End resection at double-strand breaks: mechanism and regulation.Regulation of homologous recombination in eukaryotes.Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.Ty1 integrase overexpression leads to integration of non-Ty1 DNA fragments into the genome of Saccharomyces cerevisiae.The MRN complex in double-strand break repair and telomere maintenance.Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joiningInitiation of DNA damage responses through XPG-related nucleasesThe generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complexCapture of extranuclear DNA at fission yeast double-strand breaksMutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activityDNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damageRegulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End ResectionBrc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 functionCritical Function of γH2A in S-PhaseMicrohomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.
P2860
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P2860
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Competition between the Rad50 ...... trand breaks but not telomeres
@ast
Competition between the Rad50 ...... trand breaks but not telomeres
@en
type
label
Competition between the Rad50 ...... trand breaks but not telomeres
@ast
Competition between the Rad50 ...... trand breaks but not telomeres
@en
prefLabel
Competition between the Rad50 ...... trand breaks but not telomeres
@ast
Competition between the Rad50 ...... trand breaks but not telomeres
@en
P2093
P2860
P50
P1476
Competition between the Rad50 ...... trand breaks but not telomeres
@en
P2093
Koichi Yoshinaga
Kunihiro Ohta
Masahiro Uritani
Masaru Ueno
Takashi Ushimaru
Yufuko Akamatsu
P2860
P304
P356
10.1128/MCB.23.15.5186-5197.2003
P407
P577
2003-08-01T00:00:00Z