Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites - Wikidata - awgldk - TriplyDB

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

http://www.wikidata.org/entity/Q35166748

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A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease Vitamin A and Alzheimer's disease Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking Amyloid-β Receptors: The Good, the Bad, and the Prion Protein Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases Breaking the Code of Amyloid-β Oligomers Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease Hijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearance Interaction between prion protein and Aβ amyloid fibrils revisited The dendritic hypothesis for Alzheimer's disease pathophysiology.Alzheimer's disease and prion protein Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1 Identification of a gene regulatory network associated with prion replication.Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs A sensitive and selective electrochemical biosensor for the determination of beta-amyloid oligomer by inhibiting the peptide-triggered in situ assembly of silver nanoparticles.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Structural imaging in early pre-states of dementia.The intersection of amyloid beta and tau at synapses in Alzheimer's disease The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.Plasma prion protein concentration and progression of Alzheimer disease.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo.Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.Modeling amyloid-beta as homogeneous dodecamers and in complex with cellular prion protein.Sod1 deficiency reduces incubation time in mouse models of prion disease Intravenous immunglobulin binds beta amyloid and modifies its aggregation, neurotoxicity and microglial phagocytosis in vitro.Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C))A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.Dextran sulfate sodium inhibits amyloid-β oligomer binding to cellular prion protein.Soluble Aβ oligomer production and toxicity.

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

http://www.wikidata.org/entity/Q35166748

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Interaction between prion prot ...... lly targeted at multiple sites

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Interaction between prion prot ...... lly targeted at multiple sites

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Interaction between prion prot ...... lly targeted at multiple sites

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Interaction between prion prot ...... lly targeted at multiple sites

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Nature Communications

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Interaction between prion prot ...... lly targeted at multiple sites

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Andrew J Nicoll

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Anthony R Clarke

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Darragh B Freir

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Dominic M Walsh

http://www.w3.org/2001/XMLSchema#string

Emmanuel Risse

http://www.w3.org/2001/XMLSchema#string

Helen R Saibil

http://www.w3.org/2001/XMLSchema#string

Igor Klyubin

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Jessica M Mc Donald

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John Collinge

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Mark A Farrow

http://www.w3.org/2001/XMLSchema#string

P2860

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Crystal structure of human prion protein bound to a therapeutic antibody

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

A beta oligomers - a decade of discovery

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

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336

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10.1038/NCOMMS1341

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2

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Emmanuel A. Asante

Michael J Rowan

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2011-06-07T00:00:00Z

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51202735

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21654636

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Prion protein family

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3156817

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