Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

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Q35176492

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Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease Inherited bradyarrhythmia: A diverse genetic background Atrial arrhythmias in inherited arrhythmogenic disorders The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat Fibroblast growth factor 23: a novel key to find hidden substrates of atrial fibrillation?Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways.Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.Graded Maximal Exercise Testing to Assess Mouse Cardio-Metabolic Phenotypes STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes.The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: risk factor and potential therapeutic target?Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Evidence for a functional role of calsequestrin 2 in mouse atrium.Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts.Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts.Accentuated vagal antagonism paradoxically increases ryanodine receptor calcium leak in long-term exercised Calsequestrin2 knockout mice.Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell type specific expression of Casq2 in the CPVT2 phenotype.High-resolution Optical Mapping of the Mouse Sino-atrial Node.[Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts.Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2 Mutation Mice

P2860

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P2860

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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