Hexokinase II: the integration of energy metabolism and control of apoptosis.
about
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncologyMondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysisHexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channelsHexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondriaDefective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflowHexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapyGlycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulationHypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1Dysregulated metabolism contributes to oncogenesisIs cancer a metabolic disease?Metabolic modulation of glioblastoma with dichloroacetateHexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibitionRegulation and cytoprotective role of hexokinase IIIHexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS productionMethyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosisMetabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling.Myc, mondo, and metabolismReduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.Exploiting unique structural and functional properties of malarial glycolytic enzymes for antimalarial drug developmentMitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.Non-classical gluconeogenesis-dependent glucose metabolism in Rhipicephalus microplus embryonic cell line BME26.Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranesThe BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles.HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinomaYeast mitochondrial interactosome model: metabolon membrane proteins complex involved in the channeling of ADP/ATPHexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stressEmerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy.The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis.Targeted drug delivery to mammalian mitochondria in living cells.Mitochondrial ion channels.The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death.Nutrient-sensing mTORC1: Integration of metabolic and autophagic signalsDelivery of nano-objects to functional sub-domains of healthy and failing cardiac myocytes.Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytesNuclear and mitochondrial signalling Akts in cardiomyocytesRegulation of hexokinase binding to VDAC
P2860
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P2860
Hexokinase II: the integration of energy metabolism and control of apoptosis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@ast
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@en
type
label
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@ast
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@en
prefLabel
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@ast
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@en
P356
P1476
Hexokinase II: the integration of energy metabolism and control of apoptosis.
@en
P2093
Jan B Hoek
John G Pastorino
P304
P356
10.2174/0929867033457269
P577
2003-08-01T00:00:00Z