Real-time observation of strand exchange reaction with high spatiotemporal resolution
about
Integrating multi-scale data on homologous recombination into a new recognition mechanism based on simulations of the RecA-ssDNA/dsDNA structureRecA: Regulation and Mechanism of a Molecular Search Engine.Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange.Fulfilling the dream of a perfect genome editing toolMechanisms and principles of homology search during recombination.DNA RECOMBINATION. Base triplet stepping by the Rad51/RecA family of recombinases.The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo.Complementary strand relocation may play vital roles in RecA-based homology recognition.RecA filament sliding on DNA facilitates homology searchEquilibrious strand exchange promoted by DNA conformational switchingForce and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein.Single-molecule views of protein movement on single-stranded DNA.Molecular mechanism of sequence-dependent stability of RecA filament.Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.Pulsed IR heating studies of single-molecule DNA duplex dissociation kinetics and thermodynamics.Single-molecule views on homologous recombination.DNA-pairing and annealing processes in homologous recombination and homology-directed repair.Structure/function relationships in RecA protein-mediated homology recognition and strand exchange.An Overview of the Molecular Mechanisms of Recombinational DNA Repair.Directed assembly of 3-nm-long RecA nucleoprotein filaments on double-stranded DNA with nanometer resolution.A time for promiscuity in a eukaryotic recombinase.Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.RecA-mediated sequence homology recognition as an example of how searching speed in self-assembly systems can be optimized by balancing entropic and enthalpic barriers.Simplified biased random walk model for RecA-protein-mediated homology recognition offers rapid and accurate self-assembly of long linear arrays of binding sites.Enhancement of RecA-mediated self-assembly in DNA nanostructures through basepair mismatches and single-strand nicks.Cooperative RecA clustering: the key to efficient homology searching.Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids.Two three-strand intermediates are processed during Rad51-driven DNA strand exchange.A change of view: homologous recombination at single-molecule resolution.Detecting 5-methylcytosine using an enzyme-free DNA strand exchange reaction without pretreatment under physiological conditions.Binding energies of nucleobase complexes: Relevance to homology recognition of DNA.Nonfilament-forming RecA dimer catalyzes homologous joint formation
P2860
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P2860
Real-time observation of strand exchange reaction with high spatiotemporal resolution
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@ast
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@en
type
label
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@ast
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@en
prefLabel
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@ast
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@en
P2860
P1433
P1476
Real-time observation of strand exchange reaction with high spatiotemporal resolution
@en
P2093
Kaushik Ragunathan
P2860
P304
P356
10.1016/J.STR.2011.06.009
P577
2011-08-01T00:00:00Z