Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation - Wikidata - awgldk - TriplyDB

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

http://www.wikidata.org/entity/Q35195434

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The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 Prevention of DNA re-replication in eukaryotic cells Preventing re-replication of chromosomal DNA.Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6 Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts Genomic instability in cancer.Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae.G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2 The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation CDC6: from DNA replication to cell cycle checkpoints and oncogenesis The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.Preferential re-replication of Drosophila heterochromatin in the absence of geminin.Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation.Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.Posttranslational protein modification in Archaea.Redundant control of rereplication in fission yeast.Initiation of eukaryotic DNA replication: conservative or liberal?Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex.Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity.Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle.Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators.A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase Control of DNA replication licensing in a cell cycle.Replication licensing--defining the proliferative state?

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P2860

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

http://www.wikidata.org/entity/Q35195434

description

1997 nî lūn-bûn

@nan

1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@ast

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@en

type

label

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@ast

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@en

prefLabel

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@ast

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@en

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P1433

Genes & Development

P1476

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

@en

P2093

D Tien

http://www.w3.org/2001/XMLSchema#string

M Muzi-Falconi

http://www.w3.org/2001/XMLSchema#string

P V Jallepalli

http://www.w3.org/2001/XMLSchema#string

T J Kelly

http://www.w3.org/2001/XMLSchema#string

P2860

Conserved initiator proteins in eukaryotes

A human protein related to yeast Cdc6p

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint

Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

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2767-2779

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scholarly article

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10.1101/GAD.11.21.2767

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21

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P478

11

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P577

1997-11-01T00:00:00Z

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13876756

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9353247

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P921

phosphorylation

P932

316667

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