Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
about
In vitro nuclear interactome of the HIV-1 Tat proteinInteractions of the human MCM-BP protein with MCM complex components and Dbf4Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.DNA binding and helicase actions of mouse MCM4/6/7 helicase.Genomic instability in cancer.Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY CdksMammalian Mcm2/4/6/7 complex forms a toroidal structureWerner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylationRoles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complexRetinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity.Identification of MCM4 as a target of the DNA replication block checkpoint system.PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry.Cdc7 kinase complex: a key regulator in the initiation of DNA replication.Replication licensing and the DNA damage checkpoint.Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteinsPhosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.Eukaryotic MCM proteins: beyond replication initiation.Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins.Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongationCyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domainPhosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulationFate of the replisome following arrest by UV-induced DNA damage in Escherichia coliProliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching.Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1.Overexpression of non‑SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma.Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.MYC Modulation around the CDK2/p27/SKP2 AxisCyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7.Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase.Intra-S-phase checkpoint activation by direct CDK2 inhibitionActivation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex.Molecular dynamics and QM/MM-based 3D interaction analyses of cyclin-E inhibitors.Site-specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c-MYC gene in the HeLa cell cycle.CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45.The role of APC/C(Cdh1) in replication stress and origin of genomic instability.
P2860
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P2860
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@ast
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@en
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@nl
type
label
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@ast
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@en
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@nl
prefLabel
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@ast
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@en
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@nl
P2093
P2860
P356
P1476
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
@en
P2093
P2860
P304
P356
10.1074/JBC.M909040199
P407
P577
2000-05-26T00:00:00Z