A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal
about
Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoproteinJun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.An Oct-1 binding site mediates activation of the gata2 promoter by BMP signalingErythro-megakaryocytic transcription factors associated with hereditary anemiaFOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesisA single cis element maintains repression of the key developmental regulator Gata2.GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors.Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.Hematopoietic cytokines, transcription factors and lineage commitment.GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodelingHaematopoietic and immune defects associated with GATA2 mutation.GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia.GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cellsFunctional and molecular characterization of mouse Gata2-independent hematopoietic progenitorsEctopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors.The biochemistry of hematopoietic stem cell development.GATA-1-mediated transcriptional repression yields persistent transcription factor IIB-chromatin complexes.Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus.GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.Cross talk between retinoic acid signaling and transcription factor GATA-2.Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitroHistone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation.Roles for c-Myc in self-renewal of hematopoietic stem cells.The functional duality of HoxB4 in hematopoietic reconstituting cells.
P2860
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P2860
A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@ast
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@en
type
label
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@ast
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@en
prefLabel
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@ast
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@en
P2093
P2860
P356
P1433
P1476
A GATA-2/estrogen receptor chi ...... tive regulator of self-renewal
@en
P2093
P2860
P304
P356
10.1101/GAD.13.14.1847
P577
1999-07-01T00:00:00Z