Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators.
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Mechanisms of uterine estrogen signaling during early pregnancy in mice: an updateWhat's new in estrogen receptor action in the female reproductive tractAntiestrogens: structure-activity relationships and use in breast cancer treatmentMechanistic Pathways of Sex Differences in Cardiovascular Disease.Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating ElementMutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.The role of genetics in estrogen responses: a critical piece of an intricate puzzle.Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 TreatmentOestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland.Estrogen-like potentiation of ghrelin-stimulated GH secretion by fulvestrant, a putatively selective ER antagonist, in postmenopausal women.Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized miceDifferential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitroProtective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor αTransactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function.Estrogen hormone physiology: reproductive findings from estrogen receptor mutant mice.Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterusEstrogen receptor α L543A,L544A mutation changes antagonists to agonists, correlating with the ligand binding domain dimerization associated with DNA binding activity.Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable.Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges.The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is modified.Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment.Oestrogen action and male fertility: experimental and clinical findings.Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.Activation helix orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations.Molecular mechanism of estrogen-estrogen receptor signaling.Nuclear and Membrane Actions of Estrogen Receptor Alpha: Contribution to the Regulation of Energy and Glucose Homeostasis.Hypothalamic Effects of Tamoxifen on Oestrogen Regulation of Luteinising Hormone and Prolactin Secretion in Female Rats.
P2860
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P2860
Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@ast
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@en
type
label
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@ast
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@en
prefLabel
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@ast
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@en
P2093
P2860
P356
P1476
Estrogen receptor α AF-2 mutat ...... estrogen receptor modulators.
@en
P2093
Gregory Scott
Katherine J Hamilton
Manas K Ray
Yuji Mishina
Yukitomo Arao
P2860
P304
14986-14991
P356
10.1073/PNAS.1109180108
P407
P577
2011-08-22T00:00:00Z