Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis.
about
A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cellsProgranulin in frontotemporal lobar degeneration and neuroinflammationGene discovery for the carcinogenic human liver fluke, Opisthorchis viverriniGenes and gene expression modules associated with caloric restriction and aging in the laboratory mouseThe genetics and neuropathology of frontotemporal lobar degenerationThe zebrafish progranulin gene family and antisense transcripts.Mechanisms of Progranulin Action and Regulation in Genitourinary CancersFrontotemporal Lobar Degeneration and MicroRNAsThe role of progranulin in diabetes and kidney diseaseThe Function and Roles of ADAMTS-7 in Inflammatory DiseasesStructure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activitiesA novel role for drebrin in regulating progranulin bioactivity in bladder cancerProgranulin: normal function and role in neurodegenerationProgranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteinsCartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferationCigarette smoke alters the secretome of lung epithelial cells.Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.A novel hematopoietic granulin induces proliferation of goldfish (Carassius auratus L.) macrophages.Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient micePGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistanceMiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling.IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiationProgranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathyCommon variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.Recent insights into the molecular genetics of dementiaGranulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.Mucosal Progranulin expression is induced by H. pylori, but independent of Secretory Leukocyte Protease Inhibitor (SLPI) expression.GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cellsC-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative diseaseGenetics and biology of Alzheimer's disease and frontotemporal lobar degenerationIncreased secretory leukocyte protease inhibitor (SLPI) production by highly metastatic mouse breast cancer cells.Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management.GP88 (progranulin): a novel tissue and circulating biomarker for non-small cell lung carcinoma.Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).Clinical phenotypes and genetic biomarkers of FTLD.Progranulin as a prognostic biomarker for breast cancer recurrence in patients who had hormone receptor-positive tumors: a cohort study.Characteristics of frontotemporal dementia patients with a Progranulin mutation.
P2860
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P2860
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@ast
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@en
type
label
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@ast
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@en
prefLabel
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@ast
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@en
P1476
Progranulin (granulin-epitheli ...... ssue repair and tumorigenesis.
@en
P2093
Andrew Bateman
Zhiheng He
P2888
P304
P356
10.1007/S00109-003-0474-3
P577
2003-08-19T00:00:00Z