C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. - Wikidata - awgldk - TriplyDB

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

http://www.wikidata.org/entity/Q33941320

about

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains Mechanisms of granulin deficiency: lessons from cellular and animal models Therapeutic and diagnostic challenges for frontotemporal dementia Progranulin: at the interface of neurodegenerative and metabolic diseases Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations Sortilin regulates progranulin action in castration-resistant prostate cancer cells The role of PGRN in musculoskeletal development and disease.Progranulin: a growth factor, a novel TNFR ligand and a drug target Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Progranulin regulates neuronal outgrowth independent of sortilin Insights into the role of progranulin in immunity, infection, and inflammation.Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.Progranulin: an emerging target for FTLD therapies.Endogenous growth factor stimulation of hemocyte proliferation induces resistance to Schistosoma mansoni challenge in the snail host Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Progranulin, a major secreted protein of mouse adipose-derived stem cells, inhibits light-induced retinal degeneration.Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.Progranulin axis and recent developments in frontotemporal lobar degeneration Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.New discovery rarely runs smooth: an update on progranulin/TNFR interactions Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.The role of progranulin in arthritis.Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes.Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration.Discriminatory metabolic and inflammatory parameters in serum and omental adipose tissue of obese patients with different insulin sensitivity.Progranulin and its biological effects in cancer.Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Development of a Cell-Based Assay to Assess Binding of the proNGF Prodomain to Sortilin.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.The lysosomal function of progranulin, a guardian against neurodegeneration

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P2860

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

http://www.wikidata.org/entity/Q33941320

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

@zh-tw

2011年论文

@wuu

name

C-terminus of progranulin inte ...... ulate progranulin trafficking.

@ast

C-terminus of progranulin inte ...... ulate progranulin trafficking.

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type

label

C-terminus of progranulin inte ...... ulate progranulin trafficking.

@ast

C-terminus of progranulin inte ...... ulate progranulin trafficking.

@en

prefLabel

C-terminus of progranulin inte ...... ulate progranulin trafficking.

@ast

C-terminus of progranulin inte ...... ulate progranulin trafficking.

@en

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JOURNAL.PONE.0021023

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C-terminus of progranulin inte ...... ulate progranulin trafficking.

@en

P2093

Fenghua Hu

http://www.w3.org/2001/XMLSchema#string

Owen A Brady

http://www.w3.org/2001/XMLSchema#string

Peter S Meng

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Yanqiu Zheng

http://www.w3.org/2001/XMLSchema#string

Yuxin Mao

http://www.w3.org/2001/XMLSchema#string

P2860

Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer

Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.

Progranulin is expressed within motor neurons and promotes neuronal cell survival

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy

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e21023

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scholarly article

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10.1371/JOURNAL.PONE.0021023

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21698296

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3115958

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