The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.
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Mammalian nicotinic acetylcholine receptors: from structure to functionThree-dimensional solution structure of the complex of alpha-bungarotoxin with a library-derived peptideAn amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kineticsThree-dimensional models of non-NMDA glutamate receptorsStructure and dynamics of the pore-lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles.Incorporation of reconstituted acetylcholine receptors from Torpedo into the Xenopus oocyte membraneInorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptorsActivation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor.A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segmentThe modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunitAn energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.Structural answers and persistent questions about how nicotinic receptors work.The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library.Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: chiral recognition as a dynamic process.A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.Molecular determinants conferring alpha-toxin resistance in recombinant DNA-derived acetylcholine receptors.Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics.Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.Electrostatics and the ion selectivity of ligand-gated channels.Dynamic properties of Na+ ions in models of ion channels: a molecular dynamics study.Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships.Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions.The tyrosine phosphorylation site of the acetylcholine receptor beta subunit is located in a highly immunogenic epitope implicated in channel function: antibody probes for beta subunit phosphorylation and functionThe role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain.Peptide models for membrane channels.Nuclear magnetic resonance (NMR) analysis of ligand receptor interactions: the cholinergic system--a model.Functional expression of nicotinic acetylcholine receptors containing rat alpha 7 subunits in human SH-SY5Y neuroblastoma cells.Molecular dynamics study of water and Na+ ions in models of the pore region of the nicotinic acetylcholine receptor.The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics.A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.Dissecting the chemistry of nicotinic receptor-ligand interactions with infrared difference spectroscopy.Expression of foetal type acetylcholine receptor is restricted to type 1 muscle fibres in human neuromuscular disorders.Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor.Gender differences in the pharmacology of nicotine addiction.Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics.Divalent cation permeability and blockade of Ca2+-permeant non-selective cation channels in rat adrenal zona glomerulosa cells.
P2860
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P2860
The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.
description
1992 nî lūn-bûn
@nan
1992 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The functional architecture of ...... and site-directed mutagenesis.
@ast
The functional architecture of ...... and site-directed mutagenesis.
@en
type
label
The functional architecture of ...... and site-directed mutagenesis.
@ast
The functional architecture of ...... and site-directed mutagenesis.
@en
prefLabel
The functional architecture of ...... and site-directed mutagenesis.
@ast
The functional architecture of ...... and site-directed mutagenesis.
@en
P2093
P2860
P1476
The functional architecture of ...... and site-directed mutagenesis.
@en
P2093
Bertrand D
Changeux JP
Devillers-Thiéry A
P2860
P304
P356
10.1017/S0033583500004352
P577
1992-11-01T00:00:00Z