Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth - Wikidata - awgldk - TriplyDB

Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

http://www.wikidata.org/entity/Q35206699

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APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions Targeting DNA repair pathways for cancer treatment: what's new?Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer Bcl2 inhibition of mitochondrial DNA repair.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes Mitochondrial metabolites extend lifespan.Colon cancer progression is driven by APEX1-mediated upregulation of Jagged Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.Human apurinic/apyrimidinic endonuclease 1.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Putative biomarkers and therapeutic targets associated with radiation resistance.Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy Chemotherapy-induced peripheral neuropathy: limitations in current prophylactic strategies and directions for future research.Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Expression pattern of apurinic/apyrimidinic endonuclease in sinonasal squamous cell carcinoma.Fusion between M2-macrophages and cancer cells results in a subpopulation of radioresistant cells with enhanced DNA-repair capacity.Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions.APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel.Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011年の論文

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Molecular Cancer Therapeutics

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

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Anirban Maitra

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Anthony L Sinn

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Changyu Shen

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David R Jones

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Glenda Scandura

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Mark R Kelley

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Melissa L Fishel

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Mircea Ivan

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N V Rajeshkumar

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Yanlin Jiang

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P2860

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

Random-effects models for longitudinal data

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

The many functions of APE1/Ref-1: not only a DNA repair enzyme

Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

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1698-1708

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10.1158/1535-7163.MCT-11-0107

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9

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10

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Karen E. Pollok

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51245644

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