2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. - Wikidata - awgldk - TriplyDB

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

http://www.wikidata.org/entity/Q35207843

about

Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer 2-Methoxyestradiol, a promising anticancer agent Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells.Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma.Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein.Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients.2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axis Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells.Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.Cardiovascular protective effects of 17beta-estradiol metabolites.Judah Folkman, a pioneer in the study of angiogenesis Interactions of antimitotic peptides and depsipeptides with tubulin.Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.Superoxide dismutase: an emerging target for cancer therapeutics.Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly.Drugs that target dynamic microtubules: a new molecular perspective Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine Pregnancy ameliorates the inhibitory effects of 2-methoxyestradiol on angiogenesis in primary sheep uterine endothelial cells High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis.2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation A second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model.2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis.Development of new cancer therapeutic agents targeting mitosis.Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents.Direct modulation of microtubule stability contributes to anthracene general anesthesia.Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.Brain sex differences and hormone influences: a moving experience?Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth.

P2860

Q24796091-90C590BA-2FDD-4900-BFBB-09B70206CC83 Q27639175-39192FD8-A040-41AD-B875-B62D7F36DC30 Q27639645-FFA17217-EA23-44C2-9586-513CA3E23FFB Q28388047-3CEA8D8C-B602-4A05-92E5-F6B78DF536E8 Q28611188-92D0B078-488C-4034-BF76-3C3FC3323C74 Q30875270-DE54C012-F400-44B7-BB01-A1F7864E9B6E Q33259077-593901EA-B5A3-4548-83CB-0E9790033E38 Q33281502-4818EF5B-E3DC-41B5-8708-7ACF5C404491 Q33294129-84E98F1C-10C0-4511-9769-DA4E9966E24B Q33704464-F578CD1F-0CD7-47B1-B25E-3A4E5D888256 Q33723517-90AD42D7-DD10-4434-8EA3-D0173F209AB1 Q34072983-788D734B-94B0-4F59-81B5-1F7FEF62BB38 Q34109712-02701088-70AE-41A7-85E7-D9EFFE1688D4 Q34208600-2BE34E17-275B-4F34-8C0A-B66153F7CA85 Q34377353-8A4B02D8-97D1-4737-83CD-5AC5EC3F40AE Q34745454-F56711AE-F8B7-46BF-8C15-87598414A874 Q34972878-045B43F0-DCA7-404E-819F-E1519F5D2FA7 Q34988257-AC30B3E5-8970-4874-AEB9-705D9AC003B6 Q35050415-2B7EA126-DEAD-4B37-9CB9-8E9C5CD4A1FC Q35117179-D53B60E9-ED35-46FF-8244-0EA92139DA63 Q35163252-56E37B79-D1E3-4A81-8E0F-0DF4EE8A04C3 Q35684785-31E410CF-7987-49AE-8070-A59E377032BF Q35856599-E30470EE-F9F8-4590-BF7D-931BC1A25756 Q35931039-98C06F84-A480-4D07-A3DF-A0A6E9144C16 Q36178314-CF3689FE-A8DA-424F-9176-5753C52A4ED6 Q36347162-59E4E466-8135-4768-816E-6915EB2FD025 Q36485290-9DDC9A01-7FC5-4BB2-9428-509BEF35A373 Q36509772-8B3C1EBB-19B3-45FC-9338-1F22F18A1C7F Q36559620-32FA7BB0-3EE1-4C7D-93C1-A21015D720DD Q36623076-910F1CD0-F07A-4CA1-A6FC-526C37B0DC50 Q36696715-23E1CEA2-D32B-495C-BF91-FF27DE2244D8 Q36772390-0ADE414C-3645-47D5-82E3-4E96E21CB5F2 Q36860049-CE4CFEBF-E540-471D-95EE-F89A35657206 Q36898998-7D95C5B1-CCCC-4B74-8EC9-E6575ED51DB8 Q37119737-603A93BF-6DCB-4638-8F2C-EA24CEE05A83 Q37135243-E5398D16-33A0-4C80-A44B-773DF7E99BFF Q37159387-11908F89-CA9A-4338-ABC0-F9865A3DB848 Q37183449-985B43A8-01D3-476A-8D1A-32B7C6BEC75E Q37188580-54666336-D55A-4C94-BB34-ABC06B0A52DD Q37192255-ACD00995-5C7B-4CAD-B145-209935384C31

P2860

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

http://www.wikidata.org/entity/Q35207843

description

1994 nî lūn-bûn

@nan

1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1994年の論文

@ja

1994年論文

@yue

1994年論文

@zh-hant

1994年論文

@zh-hk

1994年論文

@zh-mo

1994年論文

@zh-tw

1994年论文

@wuu

name

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@ast

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@en

type

label

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@ast

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@en

prefLabel

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@ast

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@en

P1433

Q35207843-5F1139E2-C4B1-4708-B0B5-335743F325E4

P1476

Q35207843-FEF45221-5372-4EF7-86A0-0E1A2E09E3B5

P2093

Q35207843-0A71AA42-8C18-4510-A6BB-C137E270A02B

Q35207843-14EB4F0C-E13B-4204-B5A2-B002D1ABD7F4

Q35207843-41AF6D79-C9EC-485E-96A6-263C9F7470D1

Q35207843-5B6B4430-343D-4512-8D64-20821FE7874A

Q35207843-741E5879-70F4-40E2-A33E-72F4F56A4F2A

P2860

Q35207843-32C94FE0-CD88-4814-B753-11D23EC1CC05

Q35207843-3D6C76F7-6377-47D3-BCEA-828FB99F3155

Q35207843-7EF9831E-7802-4DDF-A615-687012034929

Q35207843-8E7468CA-4EEB-49B5-B1A2-744C4BF2FF40

Q35207843-968C9A9B-20B0-4E2C-9279-DB62603563A8

Q35207843-989F8785-B84C-4321-97D1-665B17A5A7C7

Q35207843-9A0128A9-AA8A-42A2-B311-D0AFAE788236

Q35207843-A88CFAEA-367C-4E3A-A867-FE4005F845B7

Q35207843-A9606B60-2B14-44F2-BC7B-47CF504E37DE

Q35207843-C2551CA3-E156-4A86-ABB3-140408731DD2

P304

Q35207843-DB4E910B-6C60-4A61-8830-E9E54B69DE7D

P31

Q35207843-7E9735C9-4545-4E74-8ED3-7108E2C226CC

P356

Q35207843-7027E4D7-B537-4DD9-B72F-F83985338C79

P407

Q35207843-2A21B37B-0419-48D6-8675-ED4939AFD702

P433

Q35207843-2268C24B-D1BC-4962-954E-F2F67E3F301B

P478

Q35207843-0A2EF5DB-1D4A-4E90-8809-1E5369B74491

P577

Q35207843-55ABFA67-6D81-4755-A2E4-2DA6E62394EE

P5875

Q35207843-EE0F6207-92E9-45D8-B766-8959257803B7

P698

Q35207843-951BDB06-2D34-47DC-8868-FA65DC996C6B

P932

Q35207843-FF9D0DB3-9B32-45DD-9079-0DBDA23E1F41

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

2-Methoxyestradiol, an endogen ...... acting at the colchicine site.

@en

P2093

D'Amato RJ

http://www.w3.org/2001/XMLSchema#string

Flynn E

http://www.w3.org/2001/XMLSchema#string

Folkman J

http://www.w3.org/2001/XMLSchema#string

Hamel E

http://www.w3.org/2001/XMLSchema#string

Lin CM

http://www.w3.org/2001/XMLSchema#string

P2860

Molecules in mammalian brain that interact with the colchicine site on tubulin.

Endogenous inhibitor of colchicine-tubulin binding in rat brain.

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth.

The excretion of five different 2-hydroxyoestrogen monomethyl ethers in human pregnancy urine.

Molecular features of colchicine associated with antimitotic activity and inhibition of tubulin polymerization.

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells.

Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.

Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly.

P304

3964-3968

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.91.9.3964

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

91

http://www.w3.org/2001/XMLSchema#string

P577

1994-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

15028281

http://www.w3.org/2001/XMLSchema#string

P698

8171020

http://www.w3.org/2001/XMLSchema#string

P932

43703

http://www.w3.org/2001/XMLSchema#string