Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. - Wikidata - awgldk - TriplyDB

Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.

Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.

http://www.wikidata.org/entity/Q36696715

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Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer.2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line.Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones.Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers.Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges Effects of hormone deprivation and 2-methoxyestradiol combination therapy on hormone-dependent prostate cancer in vivo.Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line.Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors.Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis.In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.An overview of tubulin inhibitors that interact with the colchicine binding site The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer.BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells.Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors.Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.Orthotopic mouse models expressing fluorescent proteins for cancer drug discovery.2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.Putative effects of potentially anti-angiogenic drugs in rheumatic diseases.2-methoxyestradiol and disorders of female reproductive tissues.2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line The in vitro effects of 2-methoxyestradiol-bis-sulphamate on cell numbers, membrane integrity and cell morphology, and the possible induction of apoptosis and autophagy in a non-tumorigenic breast epithelial cell line.Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.Effect of formulation parameters on 2-methoxyestradiol release from injectable cylindrical poly(DL-lactide-co-glycolide) implants.Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines.

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Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.

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Pharmacokinetics and efficacy ...... sulphamate in vivo in rodents.

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2-Methoxyestradiol, a promising anticancer agent

Further evidence to support the melanocytic origin of MDA-MB-435

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.

Novel oestrogen sulfamates: a new approach to oral hormone therapy.

Estrone sulfate: production rate and metabolism in man.

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Catecholoestrogens (2-and 4-hydroxyoestrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance.

2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.

2-hydroxyestrone: the 'good' estrogen.

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