Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. - Wikidata - awgldk - TriplyDB

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.

http://www.wikidata.org/entity/Q35208075

about

Polycomb group genes: keeping stem cell activity in balance The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein Targeting EZH2 in cancer B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells Polycomb silencers control cell fate, development and cancer Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis.Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling.Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas.Polycomb preferentially targets stalled promoters of coding and noncoding transcripts Polycomb group complexes--many combinations, many functions.Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene.Zfx controls the self-renewal of embryonic and hematopoietic stem cells.The establishment and maintenance of lymphocyte identity through gene silencing.Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease.A complex Polycomb issue: the two faces of EZH2 in cancer.Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects.Epigenome programming by Polycomb and Trithorax proteins.Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.Aberrant gene silencing in tumor progression: implications for control of cancer.

P2860

Q21563548-1958D173-9A2B-427B-B6DA-6D71B77BA127 Q24294810-3CBD5562-7A6F-45DF-B9E3-741EEB99B4BF Q24313030-3CF17C95-AC5D-4D69-AB35-FB5EBF072085 Q24317211-52FB2EB2-D294-4661-BFAF-7C25B838033F Q24562340-19E2641C-1808-4800-A3E6-2CFB4CC7F56E Q24679773-5660D2AD-DC49-49AC-93E7-7E6AF1AE4233 Q26769027-278FF8F9-FFBE-486E-A7F6-C2E3F60BA8D8 Q28075362-B089F59A-37BA-4363-8030-C1DA815F7AAE Q28145079-9C88B691-DFF7-45BA-920E-65AB736866C1 Q28177142-6C2ED19C-D61D-4382-BECD-4EF6AD69605C Q28585869-E7A90EC4-2E11-4444-9E82-FE94D28475C1 Q28587596-A95CF97D-6089-4660-B35E-34A186DEF141 Q29618944-44607687-05C2-4785-A6AC-B512E8917B53 Q29619697-A1235646-2085-4C38-83E3-3D91041EC4EF Q33328634-693C983E-FECF-4260-A251-AF61EC025C42 Q33551015-2B49EA06-DDC2-4023-91A3-5A86AF3C69C4 Q33763739-32F4A598-5904-4CA5-BE28-335F7E4640F0 Q33815911-C9C22017-AA11-40AA-8BDC-E6D7179A2EE8 Q33855686-EA9B59DC-4ED5-40ED-91E3-4DB320D71855 Q34360544-4426A4AF-EA8F-4F08-B73B-31E2CF4CD456 Q34431278-92738A0E-D764-411B-B174-BB206AC584AF Q34468460-9D1C4284-CBF9-476D-81F7-73876B4283EA Q34490029-7F672244-6A5E-48AE-906C-C2BB7127986D Q34508316-98C33741-466A-41A2-91B3-EDFD9ED3BF05 Q34548266-4A2B96C3-D984-4973-ACCA-7025015F9261 Q34570800-88DDD2FB-F8EF-48F9-AB4B-B5F06A263998 Q34596329-8581F4FB-3507-4A98-BDE0-154AC19AAB03 Q34616276-9E04DAF4-24DB-495E-8517-0668B7BCD40A Q34621247-E8D1166C-B189-42C6-B0FD-76F70C715B08 Q35164198-52969687-F1BA-430A-A578-7EE44186DB4E Q35582877-74546D09-0E3A-47B0-A29E-16563E6E468A Q35825994-176630C9-BBF8-4701-8488-60184FC38773 Q35829466-F5E97D88-B572-417E-9170-4CDEB6A59629 Q35914892-AA9CB378-569D-4DE7-8CD8-EF881E4E8E6E Q35950048-B119A3E4-8B0D-4A85-AB17-63C6FE52444E Q36007595-EB79BAEE-E156-415F-8C60-C6495AFEC0C4 Q36157946-7D5891EC-6391-4E5C-96C5-F18149FDBD09 Q36164758-258C003B-67CC-4E83-895C-33AC38E71D87 Q36421331-47AC79DC-E772-4DF8-AB5E-80ED05CBB9B3 Q36547766-7C66DCA7-BEBC-4DDA-BF92-35B6BD10099C

P2860

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.

http://www.wikidata.org/entity/Q35208075

description

1999 nî lūn-bûn

@nan

1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Functional antagonism of the P ...... emopoietic cell proliferation.

@ast

Functional antagonism of the P ...... emopoietic cell proliferation.

@en

type

label

Functional antagonism of the P ...... emopoietic cell proliferation.

@ast

Functional antagonism of the P ...... emopoietic cell proliferation.

@en

prefLabel

Functional antagonism of the P ...... emopoietic cell proliferation.

@ast

Functional antagonism of the P ...... emopoietic cell proliferation.

@en

P1433

Q35208075-4DBF9979-2367-412B-8A59-17558AB9277D

P1476

Q35208075-5FFE390E-FDC0-4698-A951-C5D02F947E23

P2093

Q35208075-0F1459C1-6B7A-45D9-9FF9-84EA04E4C61A

Q35208075-112ABE67-ABCB-48BF-BA8C-5A4397697BA9

Q35208075-3399CF8C-64EF-4A52-9440-B42694556A91

Q35208075-68959813-5245-4AC3-B673-92B65B8C4310

Q35208075-C348835A-A61A-4D72-8822-ABD1DEC0AEA5

Q35208075-DC02A52D-85BA-4B79-AFE0-753BDEC61AB0

P2860

Q35208075-02579AFD-75D7-4564-83B6-1DBD1196D586

Q35208075-0567E1BD-7023-49A1-AAB7-4C817174BF64

Q35208075-14C85AD0-46DB-4738-86D1-A4D5573BEFF4

Q35208075-196B8155-0929-44D6-96E7-46A877FD0B8C

Q35208075-315933F7-4389-4AAF-A51A-0C10E924F03F

Q35208075-325FB626-515F-431C-B8FD-03E86FFEA23C

Q35208075-385D7FD7-82C5-4FB5-844D-F32266F71996

Q35208075-3A9CF73B-7CCD-4DE1-B3A7-0E690696140D

Q35208075-44231FCD-6A33-428F-A8A1-AC8C2D3C9B07

Q35208075-49861509-3628-425C-AD6B-DEB9F27435C5

P304

Q35208075-6DE27824-FEEF-420F-9217-D7FEF2381486

P31

Q35208075-847124FC-F033-4DFC-8C41-A160E57EA707

P356

Q35208075-163308A8-D6CD-48C6-9BED-15890E489DFF

P433

Q35208075-CAF6D1DF-080D-4C2F-8469-6342BCC48DEA

P478

Q35208075-1B47F12E-5F82-40B2-9745-7BC642F2DC43

P577

Q35208075-056BA726-4C8B-4556-ABAA-290394912427

P5875

Q35208075-F6CEF67C-31C8-434F-8E78-5BBF6D948DFB

P698

Q35208075-0298F5C1-2838-4F46-8929-F8C2ED3867B7

P932

Q35208075-067ACF28-C631-4854-9A2E-42C84EEF9000

P356

P1433

Genes & Development

P1476

Functional antagonism of the P ...... emopoietic cell proliferation.

@en

P2093

A Schumacher

http://www.w3.org/2001/XMLSchema#string

G Sauvageau

http://www.w3.org/2001/XMLSchema#string

J Lessard

http://www.w3.org/2001/XMLSchema#string

M van Lohuizen

http://www.w3.org/2001/XMLSchema#string

T Magnuson

http://www.w3.org/2001/XMLSchema#string

U Thorsteinsdottir

http://www.w3.org/2001/XMLSchema#string

P2860

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor

Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

Point mutations in the WD40 domain of Eed block its interaction with Ezh2.

RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic

Stage-specific expression of polycomb group genes in human bone marrow cells

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes

P304

2691-2703

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.13.20.2691

http://www.w3.org/2001/XMLSchema#string

P433

20

http://www.w3.org/2001/XMLSchema#string

P478

13

http://www.w3.org/2001/XMLSchema#string

P577

1999-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12758344

http://www.w3.org/2001/XMLSchema#string

P698

10541555

http://www.w3.org/2001/XMLSchema#string

P932

317097

http://www.w3.org/2001/XMLSchema#string