Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. - Wikidata - awgldk - TriplyDB

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

http://www.wikidata.org/entity/Q35208164

about

p16(INK4a) translation suppressed by miR-24 The function of APC/CCdh1 in cell cycle and beyond Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.p53-independent functions of the p19(ARF) tumor suppressor The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2 A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications MYC activation is a hallmark of cancer initiation and maintenance Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway SALL4 is a key regulator of survival and apoptosis in human leukemic cells Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 Activation and activities of the p53 tumour suppressor protein Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo GSK3beta regulates differentiation and growth arrest in glioblastoma Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1 Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma The polycomb repressive complex 2 is a potential target of SUMO modifications.c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion.Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.c-Myc is required for maintenance of glioma cancer stem cells.MUC1-C activates BMI1 in human cancer cells.Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.Inactivation of MYC reverses tumorigenesis.Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein.Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential.

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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

http://www.wikidata.org/entity/Q35208164

description

1999 nî lūn-bûn

@nan

1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1999 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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type

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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Bmi-1 collaborates with c-Myc ...... duced apoptosis via INK4a/ARF.

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P2093

A Berns

http://www.w3.org/2001/XMLSchema#string

B Scheijen

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J J Jacobs

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J W Voncken

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P2860

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

Induction of apoptosis in fibroblasts by c-myc protein

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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