Potential chemotherapeutic targets in the purine metabolism of parasites.
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The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi InfectionThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationCrystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and HyperactivationStructures of adenosine kinase fromTrypanosoma brucei bruceiAntiplatelet drugsCharacterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania majorCrystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.In vitro anti-malarial activity of N6-modified purine analogs.Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasisA short RNA stem-loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomesMultiple metabolic roles for the nonphotosynthetic plastid of the green alga Prototheca wickerhamii.Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicitiesIdentification and characterization of two adenosine phosphorylase activities in Mycobacterium smegmatis.Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis.Uptake of nitrobenzylthioinosine and purine beta-L-nucleosides by intracellular Toxoplasma gondiiSynthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity.Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.Kinetoplastids: related protozoan pathogens, different diseases.Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity.Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.State of the art in African trypanosome drug discovery.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.New approaches in antimalarial drug discovery and development: a review.8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research.Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES.Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni.Purine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptakeTrypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding.Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine.Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei.Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
P2860
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P2860
Potential chemotherapeutic targets in the purine metabolism of parasites.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Potential chemotherapeutic targets in the purine metabolism of parasites.
@ast
Potential chemotherapeutic targets in the purine metabolism of parasites.
@en
type
label
Potential chemotherapeutic targets in the purine metabolism of parasites.
@ast
Potential chemotherapeutic targets in the purine metabolism of parasites.
@en
prefLabel
Potential chemotherapeutic targets in the purine metabolism of parasites.
@ast
Potential chemotherapeutic targets in the purine metabolism of parasites.
@en
P1476
Potential chemotherapeutic targets in the purine metabolism of parasites.
@en
P2093
Mahmoud H el Kouni
P304
P356
10.1016/S0163-7258(03)00071-8
P577
2003-09-01T00:00:00Z