Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.
about
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondMuddled mechanisms: recent progress towards antimalarial target identificationNew Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in PlasmodiumGlobal proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogueMetabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspDMEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.The apicoplast: now you see it, now you don't.Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs.Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.
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P2860
Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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2015年學術文章
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name
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@ast
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@en
type
label
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@ast
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@en
prefLabel
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@ast
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@en
P2093
P2860
P50
P356
P1476
Plasmodium IspD (2-C-Methyl-D- ...... Druggable Antimalarial Target.
@en
P2093
Christina L Stallings
Christopher M Armstrong
Katherine M Mann
Kathryn E Price
Mary Clare Masters
Paul M O'Neill
P2860
P304
P356
10.1021/ID500047S
P577
2015-03-02T00:00:00Z