Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease - Wikidata - awgldk - TriplyDB

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

http://www.wikidata.org/entity/Q35212180

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Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease APOEε2 is associated with milder clinical and pathological Alzheimer disease.Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction.Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.Increased tauopathy drives microglia-mediated clearance of beta-amyloid.Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Enhanced Tau Aggregation in the Presence of Amyloid β.A Theoretical Analysis of the Synergy of Amyloid and Tau in Alzheimer's Disease.Interactions of pathological proteins in neurodegenerative diseases.Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease.Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.The Study of Postmortem Human Synaptosomes for Understanding Alzheimer's Disease and Other Neurological Disorders: A Review.Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum.Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals.Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.What is the evidence that tau pathology spreads through prion-like propagation?Amyloid Associated Intermittent Network Disruptions in Cognitively Intact Older Subjects: Structural Connectivity Matters.Tauopathies: Mechanisms and Therapeutic Strategies.Importance of tau in cognitive decline as revealed by developmental exposure to lead.The use of mouse models to study cell-to-cell transmission of pathological tau.Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.Computational modelling of pathogenic protein spread in neurodegenerative diseases.Association between naturally occurring anti-amyloid β autoantibodies and medial temporal lobe atrophy in Alzheimer's disease.Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

http://www.wikidata.org/entity/Q35212180

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Acta neuropathologica communications

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Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

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Amy M Pooler

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Christopher William

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David R Beier

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Eduardo A Maury

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George A Carlson

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Ozge Cagsal-Getkin

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Rose Pitstick

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Samantha B Nicholls

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P2860

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

Trans-synaptic spread of tau pathology in vivo

Alzheimer's disease: the amyloid cascade hypothesis

Tau suppression in a neurodegenerative mouse model improves memory function

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Propagation of tau pathology in a model of early Alzheimer's disease

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits

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3

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Tara L Spires-Jones

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274727770

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Alzheimer's disease

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