Differential niche and Wnt requirements during acute myeloid leukemia progression - Wikidata - awgldk - TriplyDB

Differential niche and Wnt requirements during acute myeloid leukemia progression

Differential niche and Wnt requirements during acute myeloid leukemia progression

http://www.wikidata.org/entity/Q35212397

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Aberrant Wnt Signaling in Leukemia Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Hematopoietic stem cell niche maintenance during homeostasis and regeneration Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data.Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.Osteoblasts as leukemia-initiating cells.Induction of histiocytic sarcoma in mouse skeletal muscle.Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation.Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.Myelodysplasia is in the niche: novel concepts and emerging therapies.Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.The regulation of normal and leukemic hematopoietic stem cells by niches.The clinical significance of γ-catenin in acute myeloid leukemia Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity.The hematopoietic stem cell niche--home for friend and foe?From seeing to believing: labelling strategies for in vivo cell-tracking experiments.Wnt signaling in leukemias and myeloma: T-cell factors are in control.Normal and leukemic stem cell niches: insights and therapeutic opportunities.The Wnt signaling pathway in cancer.Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling.Hypothesis: Tim-3/galectin-9, a new pathway for leukemia stem cells survival by promoting expansion of myeloid-derived suppressor cells and differentiating into tumor-associated macrophages.Myeloid malignancies and the microenvironment.The TPO/c-MPL pathway in the bone marrow may protect leukemia cells from chemotherapy in AML Patients.The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia.Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia.Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled.High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.Feedback mechanisms control coexistence in a stem cell model of acute myeloid leukaemia.Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Differential niche and Wnt requirements during acute myeloid leukemia progression

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Charles P Lin

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Christine Ragu

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Cristina Lo Celso

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D Gary Gilliland

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David A Williams

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David T Scadden

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Francesca Ferraro

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Lars Bullinger

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Scott A Armstrong

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Sebastian Shterental

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P2860

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Osteoblastic cells regulate the haematopoietic stem cell niche

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells.

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2849-2856

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10.1182/BLOOD-2011-03-345165

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