Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression - Wikidata - awgldk - TriplyDB

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

http://www.wikidata.org/entity/Q35214758

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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase Vascular aspects of cognitive impairment and dementia The pathobiology of vascular dementia Hypertension: a harbinger of stroke and dementia Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer's disease Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1 The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Biological changes associated with healthy versus pathological aging: a symposium review.Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.Viable mouse gene ablations that robustly alter brain Aβ levels are rare.Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology Association between total-Tau and brain atrophy one year after first-ever stroke.Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.The neurovascular unit in brain function and disease.Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Effect of aging on cellular mechanotransduction Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease.Optical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy.Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia Blood pressure and dementia - a comprehensive review.Two novel DNA motifs are essential for BACE1 gene transcription Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis.

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

http://www.wikidata.org/entity/Q35214758

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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type

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

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PNAS.0606298103

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Proceedings of the National Academy of Sciences of the United States of America

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Hypoxia facilitates Alzheimer' ...... gulating BACE1 gene expression

@en

P2093

Fang Cai

http://www.w3.org/2001/XMLSchema#string

Guiqiong He

http://www.w3.org/2001/XMLSchema#string

Hong Qing

http://www.w3.org/2001/XMLSchema#string

L Eric Huang

http://www.w3.org/2001/XMLSchema#string

Weihui Zhou

http://www.w3.org/2001/XMLSchema#string

Xiulian Sun

http://www.w3.org/2001/XMLSchema#string

P2860

BACE (beta-secretase) modulates the processing of APLP2 in vivo

Pathways towards and away from Alzheimer's disease

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

Regulation of angiogenesis by hypoxia: role of the HIF system

Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center.

Hydergine for dementia.

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants.

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18727-18732

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scholarly article

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10.1073/PNAS.0606298103

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P433

49

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103

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Frederick A. Dobie

Matthias Staufenbiel

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2006-11-22T00:00:00Z

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6676037

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17121991

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Alzheimer's disease

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1693730

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