The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. - Wikidata - awgldk - TriplyDB

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

http://www.wikidata.org/entity/Q35216878

about

mTOR signaling in growth control and disease Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions Nutrient sensing, metabolism, and cell growth control MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: a Children's Oncology Group Study.Regulation of mTORC1 and its impact on gene expression at a glance.The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.Metabolic circuits in neural stem cells.The changes of lipid metabolism in advanced renal cell carcinoma patients treated with everolimus: a new pharmacodynamic marker?Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs A quantitative transcriptomic analysis of the physiological significance of mTOR signaling in goat fetal fibroblasts MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis.mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.The multifaceted role of mTORC1 in the control of lipid metabolism mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.A viral kinase mimics S6 kinase to enhance cell proliferation.Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming.Exploiting p70 S6 kinase as a target for ovarian cancer.Temsirolimus: a safety and efficacy review.A growing role for mTOR in promoting anabolic metabolism.Rapamycin-resistant effector T-cell therapy.mTOR signaling in T cell immunity and autoimmunity.Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions.Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.The interplay between cell signalling and the mevalonate pathway in cancer.Role of Metabolism in the Immunobiology of Regulatory T Cells.m-TOR inhibitors and their potential role in haematological malignancies.Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases.Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes.Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation.The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.A Molecular Cascade Modulates MAP1B and Confers Resistance to mTOR Inhibition in Human Glioblastoma.

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P2860

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

http://www.wikidata.org/entity/Q35216878

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

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2011年論文

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2011年論文

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2011年论文

@wuu

name

The mammalian target of rapamy ...... stant transcriptional profile.

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The mammalian target of rapamy ...... stant transcriptional profile.

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type

label

The mammalian target of rapamy ...... stant transcriptional profile.

@ast

The mammalian target of rapamy ...... stant transcriptional profile.

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prefLabel

The mammalian target of rapamy ...... stant transcriptional profile.

@ast

The mammalian target of rapamy ...... stant transcriptional profile.

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PNAS.1103746108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The mammalian target of rapamy ...... istant transcriptional profile

@en

P2093

Andrea J Barczak

http://www.w3.org/2001/XMLSchema#string

Beatrice T Wang

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Rebecca Barbeau

http://www.w3.org/2001/XMLSchema#string

P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Positional cloning of the combined hyperlipidemia gene Hyplip1

Knockin of mutant PIK3CA activates multiple oncogenic pathways

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

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15201-15206

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scholarly article

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10.1073/PNAS.1103746108

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37

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108

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Gregory S Ducker

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2011-08-29T00:00:00Z

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51604065

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21876130

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3174577

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