Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. - Wikidata - awgldk - TriplyDB

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

http://www.wikidata.org/entity/Q35221417

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The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.Insulin receptor substrates (IRSs) and breast tumorigenesis.p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer.IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.Increased expression of IRS-1 is associated with lymph node metastasis in nasopharyngeal carcinoma.Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer.The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer.Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.Metastasis suppressors and their roles in breast carcinoma.Cell survival and metastasis regulation by Akt signaling in colorectal cancer Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.Expression and function of the insulin receptor substrate proteins in cancer Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells.Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion.Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development.Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells.Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1.Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death.MiR-23a-mediated migration/invasion is rescued by its target, IRS-1, in non-small cell lung cancer cells.Extrusion of misfolded and aggregated proteins--a protective strategy of aging neurons?Identification of a novel invasion-promoting region in Insulin Receptor Substrate 2 (IRS2).IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma.The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View.Association of IRS2 overexpression with disease progression in intrahepatic cholangiocarcinoma

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Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

http://www.wikidata.org/entity/Q35221417

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@ast

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

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type

label

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@ast

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@en

prefLabel

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@ast

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@en

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P1433

Molecular and Cellular Biology

P1476

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

@en

P2093

Junran Zhang

http://www.w3.org/2001/XMLSchema#string

Leslie M Shaw

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Maura A Byrne

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Morris F White

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Shannon L Gibson

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Zhefu Ma

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P2860

The Hallmarks of Cancer

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins

Disruption of IRS-2 causes type 2 diabetes in mice

Stromal effects on mammary gland development and breast cancer

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

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10.1128/MCB.01032-06

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24

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26

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2006-10-09T00:00:00Z

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6763821

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17030605

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1698550

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