Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. - Wikidata - awgldk - TriplyDB

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.

http://www.wikidata.org/entity/Q35223274

about

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice Maspin is not required for embryonic development or tumour suppression The PI3K/Akt Pathway in Tumors of Endocrine Tissues Diverse mechanisms of AKT pathway activation in human malignancy The mutational landscape of prostate cancer Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor PTEN plasticity: how the taming of a lethal gene can go too far Turning off AKT: PHLPP as a drug target Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells Suppression of survival signalling pathways by the phosphatase PHLPP Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis.Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.Akt: a double-edged sword in cell proliferation and genome stability.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.Molecular pathways and targets in prostate cancer Constitutive activity of the androgen receptor.Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.Viewing serine/threonine protein phosphatases through the eyes of drug designers Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error.MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine.Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer.PTEN at a glance.Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors Lower expression of PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) association with poor prognosis of gastric cancer Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)Achieving specificity in Akt signaling in cancer.Recent progress in mouse models for tumor suppressor genes and its implications in human cancer.PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.FANCI is a negative regulator of Akt activation.Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.

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Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.

http://www.wikidata.org/entity/Q35223274

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2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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J.CCR.2011.07.013

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Identification of PHLPP1 as a ...... t prostate cancer progression.

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

The phosphatase PHLPP controls the cellular levels of protein kinase C

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Targeting the PI3K signaling pathway in cancer

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Pten dose dictates cancer progression in the prostate

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock

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