Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.
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Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunityB cell abnormalities in systemic lupus erythematosusInducible resistance to Fas-mediated apoptosis in B cells.Biology of chronic lymphocytic leukemia.Rescue of self-reactive B cells by provision of T cell help in vivo.CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus.Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus.Loss of the proapoptotic protein, Bim, breaks B cell anergyAntigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse model.Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded.Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cellsICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulationTolerant anti-insulin B cells are effective APCsB-cell anergy: from transgenic models to naturally occurring anergic B cells?Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation.Tuning of CD40-CD154 interactions in human B-lymphocyte activation: a broad array of in vitro models for a complex in vivo situation.Transplantation tolerance: don't forget about the B cells.B cells from African American lupus patients exhibit an activated phenotype.Circulating FVIII-specific IgG, IgA and IgM memory B cells from haemophilia A patients.Whither the anergic B-cell?B-cell activation versus tolerance--the central role of immunoglobulin receptor engagement and T-cell help.The role of T cells in the regulation of B cell tolerance.Balancing immunity, autoimmunity, and self-tolerance.Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profileRole of molecular mimicry and polyclonal cell activation in the induction of pathogenic β2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid.A second heavy chain permits survival of high affinity autoreactive B cells.Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.Modulation of E2F Activity via Signaling through Surface IgM and CD40 Receptors in WEHI-231 B Lymphoma Cells
P2860
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P2860
Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@ast
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@en
type
label
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@ast
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@en
prefLabel
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@ast
Anergic self-reactive B cells ...... n-receptor-mediated functions.
@en
P2093
P2860
P356
P1476
Anergic self-reactive B cells ...... en-receptor-mediated functions
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.10.4392
P407
P577
1994-05-01T00:00:00Z