Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. - Wikidata - awgldk - TriplyDB

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

http://www.wikidata.org/entity/Q35232644

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Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism The impact of metagenomic interplay on the mosquito redox homeostasis Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy Exploiting metabolic and antioxidant pathways to maintain vision in blinding disease Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity Pretreatment of MQA, a caffeoylquinic acid derivative compound, protects against H2O2-induced oxidative stress in SH-SY5Y cells.Mechanisms and functions of Nrf2 signaling in Drosophila.Concise review: Patient-derived olfactory stem cells: new models for brain diseases.High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function.Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain.Probing mechanisms that underlie human neurodegenerative diseases in Drosophila Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.Buffering of Genetic Regulatory Networks in Drosophila melanogaster.20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.P62/SQSTM1 at the interface of aging, autophagy, and disease.Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.The aberrantly expressed long noncoding RNA in the substantia nigra and corpus striatum of Nrf2-knockout mice.Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.Nrf2: a modulator of Parkinson's disease?The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Small Maf functions in the maintenance of germline stem cells in the Drosophila testis.Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc.Mass Histology to Quantify Neurodegeneration in Drosophila.α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.ARE-inducing phenol antioxidant TC-13 improves survival of Drosophila melanogaster in oxidative stress.Aqueous extract of tomato seeds attenuates rotenone-induced oxidative stress and neurotoxicity in Drosophila melanogaster.Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

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Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

http://www.wikidata.org/entity/Q35232644

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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Genetic activation of Nrf2 sig ...... model of Parkinson's disease.

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Genetic activation of Nrf2 sig ...... model of Parkinson's disease.

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Disease Models & Mechanisms

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Genetic activation of Nrf2 sig ...... a model of Parkinson's disease

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Dirk Bohmann

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Maria Cecilia Barone

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P2860

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

Alpha-synuclein in Lewy bodies

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

Stress-activated cap'n'collar transcription factors in aging and human disease

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies

Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

A Drosophila model of Parkinson's disease

Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.

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701-707

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5

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Gerasimos P Sykiotis

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2011-06-30T00:00:00Z

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Parkinson's disease

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