Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.
about
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage ResponseHuntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine coreManifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons.Common disease signatures from gene expression analysis in Huntington's disease human blood and brainAcetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.Mutant Huntingtin Disrupts the Nuclear Pore Complex.Long Term Aggresome Accumulation Leads to DNA Damage, p53-dependent Cell Cycle Arrest, and Steric Interference in Mitosis.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.The roles of the nuclear pore complex in cellular dysfunction, aging and disease.Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract.Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease.Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
P2860
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P2860
Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Disruption of the nuclear memb ...... odels of Huntington's disease.
@ast
Disruption of the nuclear memb ...... odels of Huntington's disease.
@en
type
label
Disruption of the nuclear memb ...... odels of Huntington's disease.
@ast
Disruption of the nuclear memb ...... odels of Huntington's disease.
@en
prefLabel
Disruption of the nuclear memb ...... odels of Huntington's disease.
@ast
Disruption of the nuclear memb ...... odels of Huntington's disease.
@en
P2093
P2860
P356
P1476
Disruption of the nuclear memb ...... models of Huntington's disease
@en
P2093
Brett A Barbaro
Che-Kun James Shen
J Lawrence Marsh
Kuan-Yu Liu
Leslie Michels Thompson
Yu-Chiau Shyu
Yuan-Ta Lin
P2860
P304
P356
10.1093/HMG/DDU574
P577
2014-11-14T00:00:00Z