Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth - Wikidata - awgldk - TriplyDB

Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

http://www.wikidata.org/entity/Q35314203

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BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia Targeting BMP signalling in cardiovascular disease and anaemia Role of endoglin in fibrosis and scleroderma Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy Endoglin regulates mural cell adhesion in the circulatory system Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex Structure of bone morphogenetic protein 9 procomplex Endoglin in liver fibrogenesis: Bridging basic science and clinical practice Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer.Molecular pathways: can activin-like kinase pathway inhibition enhance the limited efficacy of VEGF inhibitors?Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis.Structural and functional insights into endoglin ligand recognition and binding.Distinct effects of unfractionated heparin versus bivalirudin on circulating angiogenic peptides.Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies.Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1 Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta.Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling.Bayesian Estimation of the Active Concentration and Affinity Constants Using Surface Plasmon Resonance Technology.High-mobility group box-1 and endothelial cell angiogenic markers in the vitreous from patients with proliferative diabetic retinopathy Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension The Prodomain-Containing BMP9 Produced from a Stable Line Effectively Regulates the Differentiation of Mesenchymal Stem Cells.BMP signaling in mesenchymal stem cell differentiation and bone formation.Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains.Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure.Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells.Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury.BMP9 signaling in stem cell differentiation and osteogenesis.Endoglin: a critical mediator of cardiovascular health Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis.Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia.The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer.Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma.Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling.Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease.TGFβ signaling and cardiovascular diseases.

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Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

http://www.wikidata.org/entity/Q35314203

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Soluble endoglin specifically ...... n, and suppresses tumor growth

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Soluble endoglin specifically ...... n, and suppresses tumor growth

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type

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Soluble endoglin specifically ...... n, and suppresses tumor growth

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Soluble endoglin specifically ...... n, and suppresses tumor growth

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Soluble endoglin specifically ...... n, and suppresses tumor growth

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Soluble endoglin specifically ...... n, and suppresses tumor growth

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JBC.M111.260133

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Journal of Biological Chemistry

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Soluble endoglin specifically ...... n, and suppresses tumor growth

@en

P2093

Aaron W Mulivor

http://www.w3.org/2001/XMLSchema#string

Asya V Grinberg

http://www.w3.org/2001/XMLSchema#string

Dianne Sako

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Eleonora Presman

http://www.w3.org/2001/XMLSchema#string

Eric D Werner

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Jasbir Seehra

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Kathryn W Underwood

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Nicolas Solban

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R Scott Pearsall

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Ravindra Kumar

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P2860

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

Bone morphogenetic protein-9 is a circulating vascular quiescence factor

Protein secondary structure prediction based on position-specific scoring matrices

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30034-30046

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scholarly article

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10.1074/JBC.M111.260133

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34

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21737454

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