Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
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Studying Cellular Signal Transduction with OMIC TechnologiesPrecision medicine for cancer with next-generation functional diagnosticsThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsMitochondrial apoptosis and BH3 mimeticsCaspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell linesActivity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypesEpstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infectionEpistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma.Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies.Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model systemConstitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.Response and resistance to BET bromodomain inhibitors in triple-negative breast cancerThe Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.How to unleash mitochondrial apoptotic blockades to kill cancers?Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cellsSystems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cellsMitochondria and the hallmarks of cancer.Logic Modeling in Quantitative Systems Pharmacology.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.Mitochondria-Judges and Executioners of Cell Death Sentences.Monitoring drug induced apoptosis and treatment sensitivity in non-small cell lung carcinoma using dielectrophoresis.High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xLTo Prime, or Not to Prime: That Is the Question.Dexamethasone treatment promotes Bcl-2 dependence in multiple myeloma resulting in sensitivity to venetoclax.Targeting cell death signalling in cancer: minimising 'Collateral damage'.Integrated Strategies to Gain a Systems-Level View of Dynamic Signaling Networks.Interleukin 21 - its potential role in the therapy of B-cell lymphomas.Great expectations in acute myeloid leukemia.Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinicEx vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.
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P2860
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@ast
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@en
type
label
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@ast
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@en
prefLabel
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@ast
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@en
P2093
P2860
P50
P1433
P1476
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
@en
P2093
Anthony Letai
Dalia Ercan
Huiying Piao
Karen Cichowski
Neil S Horowitz
Ophélia Maertens
Pasi A Jänne
Philip C Amrein
Ross S Berkowitz
Ursula Matulonis
P2860
P304
P356
10.1016/J.CELL.2015.01.042
P407
P577
2015-02-01T00:00:00Z