Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein.
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The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cellsStructural and functional implications of the QUA2 domain on RNA recognition by GLD-1Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modificationsWilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequenceFunction of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expressionTranscriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary developmentThe Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactionsAmine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development.Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemiasAnalysis of genetic interaction networks shows that alternatively spliced genes are highly versatile.Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1Genetic profile of acute myeloid leukemia.Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locusWilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1.Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensembleIntrinsic disorder in transcription factors.Artificial zinc finger DNA binding domains: versatile tools for genome engineering and modulation of gene expression.New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.The mammalian ovary from genesis to revelation.Roles of intrinsic disorder in protein-nucleic acid interactions.Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells.Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter.Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks.The six zinc fingers of metal-responsive element binding transcription factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities.Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and -KTS isoforms-From initial observations to recent global genomic analyses.Wilms' tumour 1 (WT1) in development, homeostasis and disease.Broad and unexpected phenotypic expression in Greek children with steroid-resistant nephrotic syndrome due to mutations in the Wilms' tumor 1 (WT1) gene.Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-κB and silenced by DNA methylation.
P2860
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P2860
Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Molecular basis for modulation ...... lms' tumor suppressor protein.
@ast
Molecular basis for modulation ...... lms' tumor suppressor protein.
@en
type
label
Molecular basis for modulation ...... lms' tumor suppressor protein.
@ast
Molecular basis for modulation ...... lms' tumor suppressor protein.
@en
prefLabel
Molecular basis for modulation ...... lms' tumor suppressor protein.
@ast
Molecular basis for modulation ...... lms' tumor suppressor protein.
@en
P2860
P356
P1476
Molecular basis for modulation ...... lms' tumor suppressor protein.
@en
P2093
P2860
P304
11932-11935
P356
10.1073/PNAS.97.22.11932
P407
P577
2000-10-01T00:00:00Z