Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.
about
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motifThe replication initiation protein Sld2 regulates helicase assembly.Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication InitiationThe Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.Mcm10 coordinates the timely assembly and activation of the replication fork helicase.A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.Dpb11 may function with RPA and DNA to initiate DNA replicationInteraction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases.Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.Mechanisms and regulation of DNA replication initiation in eukaryotes.Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.
P2860
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P2860
Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Enabling association of the GI ...... nd single-stranded origin DNA.
@ast
Enabling association of the GI ...... nd single-stranded origin DNA.
@en
type
label
Enabling association of the GI ...... nd single-stranded origin DNA.
@ast
Enabling association of the GI ...... nd single-stranded origin DNA.
@en
prefLabel
Enabling association of the GI ...... nd single-stranded origin DNA.
@ast
Enabling association of the GI ...... nd single-stranded origin DNA.
@en
P2860
P356
P1476
Enabling association of the GI ...... nd single-stranded origin DNA.
@en
P2093
Diane M Kanter
P2860
P304
36414-36426
P356
10.1074/JBC.M111.282822
P407
P577
2011-08-24T00:00:00Z